Institut Paoli-Calmettes

A single-cell atlas of large B cell lymphomas reveals distinct malignant archetypes predictive of clinical outcomes

Large B cell lymphomas (LBCLs) exhibit significant heterogeneity which leads to disparate treatment response, with up to 40% of patients developing refractory disease or relapsing within the first two years. To understand the cellular and molecular basis of this heterogeneity, we...

Guidance for laboratory implementation, governance and continuous assurance of artificial intelligence in histopathology

Abstract Artificial intelligence (AI) is rapidly transforming histopathology, with applications ranging from workflow optimisation and quality assurance to tumour diagnosis, grading, biomarker assessment and estimation of prognosis. While numerous AI algorithms have demonstrated...

Fewer players, bigger opportunity: How structural rule modifications shape physical and technical demands in youth rugby union

Purpose Youth rugby governing bodies have progressively revised competition formats to align game demands with children's developmental characteristics. However, empirical evidence remains limited on whether these structural modifications increase children's locomotor and technic...