Institut Interdisciplinaire de Neuroscience

Double periodicity of the AnkyrinG-associated complex in the axon initial segment

The axon initial segment (AIS), situated within the first 20 to 60 µm of the axon, is essential for action potential generation and maintenance of axonal identity [M. N. Rasband, Nat. Rev. Neurosci. 11 , 552–562 (2010)]. Its structure relies on the beta (β)-IV-spectrin/AnkyrinG (...

Wild-type and mutated ß-catenin differently repress RND3/RHOE expression in hepatocellular carcinoma

Tumor development and progression are mainly driven by oncogenic mutations but are also regulated by physical factors. Through its structural and transcriptional functions, ß-catenin is a key factor that acts on both aspects to promote liver tumorigenesis, leading to hepatocellul...

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

We developed a high-content screening to investigate how Alzheimer’s disease (AD) genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures. Of the target genes identified, we found that Plcg2 downregulation in mouse dentate gyrus neurons consistently d...