Institut du Thorax

Breast cancer metabolism and responsiveness to dichloroacetate: relationships with 15N and 13C natural abundance

Abstract Background Metabolic reprogramming is a hallmark of breast cancer (BrCa), with alterations in glycolysis, glutamine metabolism, and the urea cycle contributing to tumour progression. Dichloroacetate (DCA), a pyruvate dehydrogenase kinase (PDK) inhibitor, shifts metabolis...