Institut du cancer Rosalind & Morris Goodman

PTPN2 sustains non-canonical inflammasome activation and shapes the inflammatory response to sepsis

Abstract The innate immune system relies on pattern recognition receptors to recognize and detect pathogens. Gram-negative bacteria release LPS-rich outer membrane vesicles (LPS-OMVs), which activate PRRs, trigger inflammation at distant sites and contribute to systemic inflammat...