Institution
Institut d'Investigació Biomédica de Bellvitge
Recent research
- BiologyOpen access
A GPRC5B–Fyn signaling axis regulates VRAC activity by targeting LRRC8A
The mechanisms by which physiological signals gate the volume-regulated anion channel (VRAC) remain poorly understood. Here, we identify a GPRC5B–Fyn signaling axis that directly controls VRAC activation by targeting the essential subunit LRRC8A. We found that the orphan G protei...
- Health & MedicineOpen access
Background In classic Hodgkin lymphoma (cHL), identifying high-risk patients is crucial for tailored treatment. Clinical risk factors are useful, but there is room for improvement. Although many diagnostic tissue-based biomarkers have been described to correlate with prognosis, n...
- Society & EconomicsOpen access
Despite advances in cancer treatment, the growing global cancer burden underscores the need for comprehensive and supportive care to address the needs of patients and their families. However, access to psycho-oncological support remains often limited across healthcare systems. Th...
- Health & MedicineOpen access
Food addiction (FA) has been proposed as a behavioural phenotype linked to obesity, potentially influencing adherence and response to lifestyle interventions. Its role within long-term, multicomponent weight-loss programmes remains unclear. This study evaluated the impact of an i...
- BiologyOpen access
Abstract Epilepsy is characterized by the occurrence of at least two unprovoked seizures occurring more than 24 h apart, reflecting a predisposition to recurrent epileptic events. The role of dietary amino acids (AAs) in epilepsy is not clearly understood. To the best of our know...
- Health & MedicineOpen access
Growing evidence suggests genetic basis in familial and other types of fibrotic interstitial lung disease (ILD). Genetics may improve diagnostic accuracy and risk stratification. The objective was to evaluate the utility of integrating genetic data into ILD clinical practice. A r...
- BiologyOpen access
Pancreatic ductal adenocarcinoma (PDAC) develops within a nutrient-poor microenvironment, where pancreatic cancer stem cells (PaCSCs) can persist despite limited oxygen and nutrient availability. This resilience partially relies on mitochondrial metabolic flexibility. Serine and...
- BiologyOpen access
α-Parvin regulation of cell rearrangement is critical for ureteric bud branching morphogenesis
All branched tubular structures, including the kidney collecting system, are formed by branching morphogenesis, a process that includes tip branching and trunk narrowing. Tight control of cell movement and rearrangement is a prerequisite for branching morphogenesis. The role of i...
- Health & MedicineOpen access
Background/Objectives: Remission and low disease activity (LDA) are established treatment targets in rheumatoid arthritis (RA), but they may not imply normalization of patient-perceived disease burden. Fatigue and health-related quality of life (HRQoL) provide complementary measu...
- Health & Medicine
Importance: Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibition is recommended as second- or third-line lipid-lowering therapy after myocardial infarction (MI), resulting in prolonged periods of inadequate low-density lipoprotein cholesterol (LDL-C) control. Whether...
- BiologyOpen access
Ultraslow brain dynamics as neurophysiological markers of information sampling during learning
To learn, we must actively sample information from our environment: selecting, prioritizing, and extracting relevant cues. Here, we investigated whether ultraslow event-related potentials (ERPs) could track information sampling as participants learned new words from sentence cont...
- Biology
Ciliogenic pancreatopathy reveals a link between ciliopathies and exocrine pancreatic disease
Abstract Background While pancreatic cysts have been described in syndromic ciliopathies, the pancreas is not commonly recognized as a target organ. However, several ciliary gene knockout mouse models develop a pancreatic phenotype combining acinar atrophy and adipocyte accumulat...
- Health & MedicineOpen access
Abstract Hematopoietic cell transplantation, cellular and gene therapies, and (CAR)-T cells have revolutionized outcomes in hematologic disorders. However, major disparities persist in their availability, accessibility, and affordability, particularly in low- and middle-income co...
- BiologyOpen access
Triple-negative breast cancer (TNBC) accounts for 10–15% of newly diagnosed breast cancer, and its aetiology is poorly understood compared to other breast cancer subtypes. We applied untargeted metabolomics to identify novel biological pathways associated with TNBC risk and poten...
- BiologyOpen access
Aging is associated with progressive metabolic dysfunction and cognitive decline, which is often accompanied by hippocampal dysfunction and sex-specific vulnerabilities. Caloric restriction (CR) and sodium butyrate (NaBu), a short-chain fatty acid that acts as a histone deacetyla...
- Health & MedicineOpen access
Tobacco use remains disproportionately high among people receiving treatment for alcohol or cannabis use, yet it is rarely addressed in substance use services. This study explored the lived experiences of people who smoke while undergoing treatment for alcohol and/or cannabis use...
- Health & MedicineOpen access
Genetic Testing After Heart Transplantation Uncovers Heritable Disease and Drives Family Screening
BACKGROUND: Genetic testing (GT) is established in ambulatory cardiomyopathy (CM), but its utility after heart transplantation (HTx) recipients remains poorly characterized. OBJECTIVES: This study aimed to evaluate the clinical utility of GT in adult HTx recipients with CM, focus...