Institut des Maladies Métaboliques et Cardiovasculaires

Low diet quality increases the genetic risk of high blood cholesterol levels in Asian Indian adults [CURES – 165]

Background Asian Indians face an increased burden of cardiometabolic diseases, yet the interplay between genetic predisposition and diet quality in this population remains underexplored. This study aimed to examine their interaction on cardiometabolic traits in this population. M...

Association Between a 3D ‐Printed Simulation Model and Self‐Assessed Confidence in Dental Trauma Management

ABSTRACT Introduction and Aim Simulation‐based learning using 3D‐printed models offers a promising approach to improve confidence in complex procedures. Dental trauma can lead to severe functional and esthetic consequences if not managed promptly and effectively. This study aimed...

Metformin reverses lymphatic mitochondrial dysfunction induced by 5-FU chemotherapy

Abstract In western countries, secondary lymphedema often occurs after cancer treatments. However, lymphedema appears months, sometimes years after treatment suggesting that it is not only a side effect of surgery and may be promoted in part by cancer treatments. In this study, w...

Integrated adipose tissue transcriptomic and miRNA remodeling identifies molecular pathways associated with residual cardiovascular risk after weight loss

Abstract Background Weight loss improves cardiometabolic health, yet substantial inter-individual variability remains in residual cardiovascular risk. Here, we investigated whether post-weight loss adipose tissue (AT) molecular remodeling is associated with this variability. Meth...

Androgen receptor imprints satellite cell stemness and preserves their reservoir for lifelong regeneration and optimal repair

Skeletal muscle stem cells (MuSC) are the guardians of muscle regeneration, sustaining tissue integrity through a delicate balance of quiescence, activation, and lineage commitment. While numerous molecular cues have been implicated in regulating these processes, the influence of...

Association of plasma growth differentiation factor-15 with the frailty phenotype – Evidence from the COGFRAIL study

Background Growth differentiation factor-15 (GDF-15) has been consistently associated with physical frailty. However, it remains unclear whether GDF-15 further discriminates adverse outcomes among older adults who are already physically and cognitively impaired. Objectives To eva...

STABILOOP, a cohort trial to assess automated insulin delivery in the management of patients living with type 1 diabetes who are eligible for islet transplantation

A limited subset of people living with type 1 diabetes (T1D) is affected by extreme glycemic lability and frequent unpredictable severe hypoglycemia, significantly impairing quality of life and associated with higher morbidity, mortality, and healthcare costs. Islet transplantati...

Towards Personalized Medicine in Chronic Kidney Disease: A Roadmap for the future of Early Detection, Diagnosis, and Management: A Consensus Roadmap from the EUTox, PerMedik and KidneyHealth networks

Chronic kidney disease (CKD) affects more than 800 million individuals worldwide and represents one of the fastest‑growing causes of morbidity and mortality. Despite major therapeutic advances, CKD is frequently detected only after substantial and irreversible loss of kidney func...