Institut de Pharmacologie et de Biologie Structurale

Lipid-mediated GPR32 signaling reprograms macrophage metabolism to impair anti-tuberculous immunity

Abstract Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), has evolved strategies to evade innate immunity and establish persistent infection. However, the mechanisms by which M. tuberculosis reprograms human macrophage metabolism remain incompletely defined....

A cytidine deaminase biodegrader sensitises multiple cancer types to deoxycytidine analogue-based chemotherapies

Abstract Deoxycytidine (dC) analogues are widely used to treat solid tumours and blood cancers. However, their clinical efficacy is often limited by resistance mediated by cytidine deaminase (CDA), which converts these drugs into inactive metabolites. Existing CDA inhibitors have...

TurboID ‐based proteomic profiling reveals proxitome of the IRT1 metal transporter and new insight into IRT1 endocytosis

Summary Iron Regulated Transporter1 (IRT1) is the major root iron transporter responsible for broad‐spectrum metal absorption in Arabidopsis thaliana root epidermal cells. Non‐iron metal substrates of IRT1 were recently shown to regulate IRT1 cell surface levels by endocytosis an...