Institut de Myologie

Impact of chronic doxycycline treatment in a mouse model of tauopathy

Tauopathies are neurodegenerative disorders characterized by the accumulation of hyperphosphorylated tau, leading to synaptic dysfunction, neuroinflammation, and both cognitive and motor impairments. Doxycycline (Doxy), a tetracycline antibiotic commonly used to treat bacterial i...

Genetic screening identifies WNT5A/RYK as a determinant of extracellular vesicle fate

Extracellular vesicles (EVs) are natural mediators of intercellular communication through the transfer of cytoplasmic material from donor to recipient cells. The molecular mechanisms governing EV uptake and cargo delivery in recipient cells remain largely elusive. To address this...