Institut de Génomique Fonctionnelle

Evaluating the roles of testosterone and sex-linked genes in territorial aggression of sex-reversed XY females in the African pygmy mouse

Sex differences in social aggression are widespread across the animal kingdom, with males typic-ally displaying greater territoriality. While this dimorphism has traditionally been attributed to sex hormones, sex chromosomes can also contribute to it independently of hormonal inf...

Beyond correlation: Intraclass correlation and bland-altman analysis reveal poor absolute agreement across multiplex cytokine immunoassay platforms

Cross-platform comparisons of serum cytokine immunoassays have often focused on rank correlation, but the extent of absolute agreement and systematic bias between platforms remains insufficiently characterized. Few independent head-to-head evaluations have compared multiple immun...

The elongation of Mest transcript into MestXL sustains, but does not initiate, the maternal allele bias of its convergent gene Copg2 during neurogenesis

Abstract Precise gene dosage control is critical for cellular identity and development, particularly for imprinted genes, where dosage imbalances are linked to neurodevelopmental disorders. The Mest/Copg2 imprinted locus exemplifies this fine-tuned regulation: while Mest is const...

Complement C3a receptor expression is associated with distinct immune microenvironmental profiles in clear cell renal cell carcinoma

The complement receptor C3aR has emerged as an important regulator of tumor–immune interactions in several solid cancers. However, its cellular distribution and relationship with the immune microenvironment in clear cell renal cell carcinoma (ccRCC) remain poorly understood. Here...

Sensory plasticity of dorsal horn silent neurons as a critical mechanism for neuropathic pain

The spinal cord dorsal horn (DH) integrates sensory processing but undergoes critical plasticity following nerve injury, leading to mechanical allodynia, or “touch-evoked pain”. It has been proposed that after nerve injury, innocuous sensory neurons gain access to nociceptive-spe...

Cost-utility study of cognitive-behavioural management of auditory hallucinations in schizophrenia: a study protocol

Abstract Background Auditory verbal hallucinations (AVHs) affect 60–80% of patients with schizophrenia, causing significant distress and functional impairment. Although cognitive-behavioural therapy (CBT) has been shown to reduce AVH-related distress and relapse risk, its use rem...

Conserved dimerization architecture in C‐type lectins from virus‐vector mosquitoes

Abstract C-type lectins (CTLs) play key roles in innate immunity and microbial carbohydrate recognition. In the disease vector mosquito Aedes aegypti , the CTLD-S family comprises 34 soluble CTLs whose members are implicated in flavivirus dissemination and microbial homeostasis,...