Institut de Cancérologie de Lorraine

Randomized phase III trial with a factorial design assessing the efficacy and safety of darolutamide and stereotactic dose-escalated radiotherapy in patients with high-risk localized prostate cancer: the PEACE 7 (GETUG-AFU 45) study protocol

Approximately 15% of patients with localized prostate cancer harbor high risk features. Nowadays, the standard of care for such patients is the combination of androgen deprivation therapy (ADT) plus radiotherapy (hypofractionated or conventional dose escalated radiotherapy). A su...

Research Study Attrition and Participant-Informed Retention Strategies Among Cancer Survivors

Importance Attrition in longitudinal cancer cohorts compromises data completeness, introduces bias, and limits generalizability. Objective To quantify nonresponsiveness over time in a contemporary cohort of cancer survivors, identify individual- and center-level factors associate...

Cerebrospinal fluid cell-free DNA sequencing in pediatric CNS tumors: towards liquid molecular neuropathology

Pediatric central nervous system tumors remain a leading cause of cancer-related mortality in children, while their diagnosis, risk stratification, and therapeutic management increasingly depend on integrated molecular characterization. However, representative tumor tissue is oft...

Case report of transoral excision of a right buccal/jugal lipoma

Introduction: Lipomas are benign mesenchymal tumors that rarely occur in the oral cavity. Lesions arising in the jugal region may pose diagnostic and surgical challenges due to their anatomical location. We report a case of a jugal lipoma successfully managed through a transoral...

Adipose tissue and myosteatosis measured by artificial intelligence as a predictor of overall survival in bladder cancer

Body composition may influence outcomes in muscle-invasive bladder cancer (MIBC), but its prognostic role remains unclear. In particular, the impact of adipose tissue distribution and muscle quality beyond BMI has been insufficiently studied. This study aimed to evaluate whether...