Institut de Biologie Valrose

Pure Shift 2D NMR with Water Suppression for Structural and Dynamic Analysis of Flexible Molecules

Abstract Achieving high-resolution proton NMR spectra in aqueous media remains a major challenge for structurally complex and conformationally flexible molecules, where homonuclear scalar couplings and limited chemical-shift dispersion lead to severe spectral congestion. Here, we...

Ginzburg–Landau Minimizers with High Topological Degrees in an Annulus

Abstract. Motivated by recent experiments on fermionic rings, we study the asymptotic behavior of minimizers of the Ginzburg–Landau (GL) energy in an annulus with a Dirichlet data which depends on the GL parameter on the outer boundary. We show that there is a critical degree of...

Near-Infrared Organic Structures with Extended Lifetimes to Unlock the Potential of In Vivo Fluorescence Lifetime Imaging

Abstract In vivo fluorescence lifetime imaging (FLI) is an advanced optical imaging modality with the capability to reveal additional biological information compared to fluorescence intensity (FI) imaging. In addition to enabling tissue discrimination based on microenvironmental...

Unravelling the Enantiomeric Distribution of Key Sandalwood Sesquiterpenoids by Enantioselective Gas Chromatography and Molecular Rotational Resonance

Abstract The enantiomeric distribution of α- and β-santalol in various Santalum and Osyris species of different origins was determined by the combination of enantioselective gas chromatography and chiral tagging molecular rotational resonance spectroscopy, supported by the prepar...

Sex of central neurons controls intestinal niche signalling to drive sex differences in stem cell activity and cancer susceptibility

Abstract Sex differences in cancers arising in non-reproductive organs are widespread. While sex hormones and the intrinsic sexual identity of cancer cells are well-established contributors, it is unknown whether other mechanisms are involved. Here, we reveal an unexpected source...

Dipyridamole-Coated 3D-Printed β-Tricalcium Phosphate Scaffolds: Spectrophotometric Characterization, Drug Release Kinetics, and In Vitro Evaluation to Guide Critical-Sized Bone Defect Repair Studies

Critical-sized bone defects remain a significant clinical challenge, and dipyridamole (DIPY)-coated 3D-tricalcium phosphate (β-TCP) scaffolds have shown promising osteogenic efficacy in preclinical models. However, the literature on the systematic physicochemical characterization...