Institut de Biologia Molecular de Barcelona

Interference by macro-B12: multicenter evaluation of polyethylene glycol precipitation and establishment of reference intervals using four different immunoassay methods

Abstract Objectives Macro-B12 interference is an underestimated cause of hypercobalaminemia that may lead to misleading clinical interpretations. The aims of this study were to evaluate the diagnostic performance of polyethylene glycol (PEG) precipitation for the detection of mac...

Structure of astacin and the discovery of metzincins

Abstract The X-ray crystal structure of astacin from the freshwater crayfish Astacus astacus published in 1992 was the second structural prototype of a zinc metalloendopeptidase solved after thermolysin from Bacillus thermoproteolyticus 20 years earlier. Astacin became the foundi...