Institut Claudius Regaud

The role of information and consent forms in patients’ decision-making regarding participation in oncology clinical trials

Abstract Background: Informed consent is a cornerstone of ethical clinical research. However, the increasing length and complexity of information and consent forms (ICFs) raise concerns about their effectiveness in ensuring truly informed participation. This study examined the ro...

Descriptive Analysis of Epidemiology, Demographic Characteristics, and Survival of Dedifferentiated Liposarcoma in France

Dedifferentiated liposarcoma (DDLPS) is a rare soft tissue sarcoma with limited real-world epidemiologic data. This nationwide retrospective study describes the epidemiology, management, and outcomes of DDLPS in France using the NETSARC+ national sarcoma registry. A total of 1451...

A cytidine deaminase biodegrader sensitises multiple cancer types to deoxycytidine analogue-based chemotherapies

Abstract Deoxycytidine (dC) analogues are widely used to treat solid tumours and blood cancers. However, their clinical efficacy is often limited by resistance mediated by cytidine deaminase (CDA), which converts these drugs into inactive metabolites. Existing CDA inhibitors have...

Tools for providing information to patients about high-tech medical resources for treatment of cancer

BACKGROUND AND PURPOSE: High-tech medical resources play an increasingly important role in cancer diagnosis and treatment. However, accessing information about these technologies remains challenging due to their complexity and a lack of clear information pathways to obtain reliab...

Incorporating sliding and local rigidity constraints in neural-based image registration

Image registration is widely used in various applications to estimate the deformations of moving structures in image pairs acquired at different times. Spatial regularization strategies often take a one-size-fits-all approach by imposing uniform deformation constraints across the...

Semi-parametric modelling for analysing the evolution of toxicities over time

In oncology clinical research, reporting adverse events (AEs) is absolutely essential to depict the toxicity profile of new therapeutics such as targeted therapies or immunotherapies. However, conventional methods of analysis are unable to capture the new patterns of AEs induced...

The Role of Artificial Intelligence in Optimizing Diagnosis in Prostate Cancer—A Narrative Review

Artificial intelligence (AI) is increasingly being investigated in prostate cancer (PCa) diagnosis and characterization, offering novel approaches to improve detection and risk stratification. This narrative review summarizes current evidence regarding the application of AI acros...