Inova Health System

Skeletal muscle oxidative capacity and tissue composition in heart failure with preserved ejection fraction

We compared peripheral mechanisms of exercise intolerance in heart failure with preserved ejection fraction (HFpEF) patients and healthy older adults. HFpEF patients exhibited significantly greater intermuscular steatosis and impaired whole body and quadriceps oxidative capacity...

Histology resolved proteomic characterization of the triple negative breast cancer tumor immune microenvironment

Treatment options for the highly aggressive triple-negative breast cancer (TNBC) subtype remain limited, though the immune microenvironment represents a promising therapeutic target. We conducted a histology resolved tumor microenvironment analysis of TNBC by employing deep quant...

Football Cleats and Injury Patterns in 14- to 19-Year-Old Female Football Players: The Effect of Surface, Gender-Specific Shoe Gear and Cleat Pattern

BACKGROUND: Female football (soccer) players are at increased risk for lower extremity injuries, yet prevention strategies remain based mostly on male athlete data. Modifiable extrinsic factors including footwear design and playing surface have not been well defined in youth fema...

Influence of Chronic Kidney Disease on Outcomes After Paclitaxel-Coated Balloon Angioplasty for Coronary In-Stent Restenosis

BACKGROUND: Drug-coated balloons (DCB) are superior to conventional balloon angioplasty in coronary in-stent restenosis. The influence of chronic kidney disease (CKD) on outcomes after DCB for in-stent restenosis is not well described. METHODS: A post hoc analysis of the AGENT ID...

Proteogenomic profiling defines progression-associated biology in high-risk endometrial cancer

Patients with high-risk endometrial carcinoma (HR-EC) experience substantial mortality despite multimodality therapy, molecular classification and contemporary care. We determined whether proteomic tumor programs capture lethal risk beyond established clinical and genomic classif...