Inner Mongolia People's Hospital

Features and a specific pattern of cerebral perfusion in patients with Lewy body dementia: Diagnostic ability and clinical correlations

Cerebral perfusion changes have been observed in patients with both dementia with Lewy bodies and Parkinson’s disease dementia. In this study, features of cerebral blood flow (CBF) and a specific perfusion pattern measured using arterial spin labeling (ASL) MRI for Lewy body deme...

Integrated multi-omics analyses reveal the role of PAXX in colorectal cancer progression and the tumor immune microenvironment

Abstract PAXX is a DNA double-strand break repair factor involved in classical non-homologous end joining. Although elevated PAXX expression has been reported in colon cancer, its functional role and downstream mechanisms in colorectal cancer (CRC) remain incompletely defined. Th...

Integrated Multi‐Omics Analysis Identifies HVCN1 as a Potential Mediator in Neuroendocrine–Tumor Interactions in Colorectal Cancer

ABSTRACT Objective To investigate associations among sleep‐related features, neuroendocrine alterations, and colorectal cancer (CRC)‐related molecular programs, and to identify candidate genes involved in hypothalamus–tumor interactions. Methods NHANES data were analyzed to asses...

The needs of primary family caregivers for post-discharge follow-up services for older adults with mental disorders: a qualitative study

To investigate the experiences, expectations, and barriers regarding post-discharge follow-up services among primary caregivers of older adults with mental disorders. A descriptive qualitative research design was employed. The study included 17 primary caregivers of older adults...

Sexual health as an overlooked dimension of holistic recovery after adult spine surgery: an evidence-informed narrative review

Abstract Background Sexual health is a meaningful but under-recognized dimension of recovery after spine surgery. Pain, neurological impairment, mobility, body image, psychological distress, relationship context, and procedure-specific injury may all affect postoperative sexual w...

Mechanism of miR-217 in suppressing pancreatic cancer progression by targeting ENO1

Abstract Objective This research was designed to investigate the functional impact of miR-217 in modulating proliferative activity and apoptotic processes in pancreatic carcinoma cells and to investigate its associated molecular mechanisms. Methods Five matched pairs of pancreati...

SIX1 drives acute myeloid leukemia progression by reprogramming glycolytic metabolism and impairing CD8⁺ T-cell effector function

This study aimed to investigate the role of the homeobox gene SIX1 (sine oculis homeobox homolog 1) in acute myeloid leukemia (AML) progression and to explore its underlying metabolic and immunological mechanisms. SIX1 expression was examined in human bone marrow stromal cells (H...

Retrospective comparative study of transvaginal natural orifice transluminal endoscopic surgery and vaginal sacrospinous ligament fixation for pelvic organ prolapse

Abstract Objective A retrospective analysis was performed to evaluate the clinical efficacy, perioperative indicators and safety of transvaginal natural orifice transluminal endoscopic sacrospinous ligament fixation compared to vaginal sacrospinous ligament fixation in the treatm...

Anti-HER-2-modified exosomes loaded with siRNA-STIL specifically target and inhibit the development and progression of gastric cancer

STIL is a key molecule influencing the proliferation and cell cycle of gastric cancer cells; however, STIL is also expressed in normal tissues. Therefore, designing a drug delivery system that targets gastric cancer cells is crucial for STIL-targeted therapy. In this study, we co...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...

Network analysis of frailty, sleep quality, and life satisfaction in older patients: a cross-sectional study stratified by chronic disease burden

Abstract Background Multimorbidity and chronic disease burden are common among older patients and are closely associated with frailty, poor sleep, and reduced subjective well-being. However, total-score-based analyses may obscure item-level interactions across health domains. Thi...