Inner Mongolia Medical University

A case of neonatal gastric perforation misdiagnosed as neonatal necrotizing enterocolitis

Rationale: Neonatal gastric perforation (NGP) is a rare but life-threatening neonatal acute abdominal condition. Its clinical and imaging manifestations may overlap with those of necrotizing enterocolitis (NEC), making accurate preoperative localization of the perforation site ch...

Joint associations of triglyceride-cholesterol-body weight index and glycated hemoglobin with incident diabetes: a prospective study from the CHARLS cohort

Abstract Introduction The triglyceride–cholesterol–body weight index (TCBI) integrates lipid metabolism and adiposity, whereas glycated hemoglobin (HbA1c) reflects long-term glycemic status. However, their joint association with incident diabetes remains unclear. This study exami...

An FXR-dependent cellular program for Kupffer cell pool restoration fuels liver regeneration

Abstract Liver transplantation and partial hepatectomy represent the most effective therapeutic strategies for end-stage liver diseases. However, persistent donor organ shortages have intensified clinical interest in interventions that enhance liver regeneration. The farnesoid X...

Self-reported outcomes and associated factors among patients with cancer completing Mongolian mind-body interaction therapy: a cross-sectional study

Introduction Patients with malignant tumors face physical illness and psychological distress. Mongolian mind-body interaction therapy (MMBIT) is a group-based intervention combining modern psychology with traditional Mongolian medicine. As a complementary oncology approach, MMBIT...

Lachnospiraceae in the Food–Gut Axis: A Critical Review of Dietary Modulation, Immune Regulation, and Translational Barriers

The interplay between diet, gut microbiota, and host immunity is central to food science. The Lachnospiraceae family ferments dietary fibers to produce short-chain fatty acids (SCFAs), notably butyrate and propionate, with immunomodulatory potential. This critical review distingu...

Features and a specific pattern of cerebral perfusion in patients with Lewy body dementia: Diagnostic ability and clinical correlations

Cerebral perfusion changes have been observed in patients with both dementia with Lewy bodies and Parkinson’s disease dementia. In this study, features of cerebral blood flow (CBF) and a specific perfusion pattern measured using arterial spin labeling (ASL) MRI for Lewy body deme...

Biomechanical mechanisms of manipulative reduction for pediatric type II atlantoaxial subluxation a finite element analysis with neurocentral synchondroses

To establish and validate a 6-year-old pediatric craniocervical finite element model that includes the neurocentral synchondrosis (NCS), to construct a type II atlantoaxial subluxation (AAS) model, and to identify high-risk structures during simulated rotational manipulation, the...

Paired Electrochemical Decarboxylative Amidation of α‐Ketoacids With Nitroarenes

ABSTRACT We report a paired electrochemical decarboxylative amidation of α‐ketoacids with nitroarenes for the direct synthesis of N‐aryl amides. Ferrocene‐mediated anodic decarboxylation generates acyl radicals, while cathodic reduction of nitroarenes enables the in situ generati...

The needs of primary family caregivers for post-discharge follow-up services for older adults with mental disorders: a qualitative study

To investigate the experiences, expectations, and barriers regarding post-discharge follow-up services among primary caregivers of older adults with mental disorders. A descriptive qualitative research design was employed. The study included 17 primary caregivers of older adults...

Silicon Nitride Nanofilm Functionalized Titanium Mesh for Boosting Osseointegration by Macrophage-Related Immunomodulation

Abstract Titanium mesh-supported guided bone regeneration (TM-GBR) has emerged as a clinically effective strategy for alveolar bone augmentation in complex defects, primarily through its ability to preserve osteogenic space and correct bone volume deficiencies. However, due to th...

Mechanism of miR-217 in suppressing pancreatic cancer progression by targeting ENO1

Abstract Objective This research was designed to investigate the functional impact of miR-217 in modulating proliferative activity and apoptotic processes in pancreatic carcinoma cells and to investigate its associated molecular mechanisms. Methods Five matched pairs of pancreati...

Glutathione functionalized selenium nanoparticles suppress colorectal cancer cell growth with mitochondrial dysfunction and mitophagy related remodeling

Glutathione functionalization may improve the physicochemical and biological performance of selenium nanoparticles; however, the effects of glutathione-functionalized selenium nanoparticles (GSH-SeNPs) on colorectal cancer (CRC) cells remain insufficiently defined. In this study,...

Exosomal miR-22-3p targets p53 to regulate endometrial epithelial cell function in the pathogenesis of endometriosis

Endometriosis (EMs) is a widespread gynecological disease, affecting approximately 6-10% of females of child-bearing age. Despite its significant influence on women's health, the specific pathophysiology remains unclear. The enrichment of miR-22-3p in exosomes has been implicated...

Nipple shield use in direct breastfeeding for preterm infants: a scoping review

Breastfeeding in the preterm infant population faces numerous practical challenges, and nipple shields play a crucial auxiliary role in achieving direct breastfeeding. Current related studies exhibit significant heterogeneity in design, outcome measures, and contexts, lacking a c...

Retrospective comparative study of transvaginal natural orifice transluminal endoscopic surgery and vaginal sacrospinous ligament fixation for pelvic organ prolapse

Abstract Objective A retrospective analysis was performed to evaluate the clinical efficacy, perioperative indicators and safety of transvaginal natural orifice transluminal endoscopic sacrospinous ligament fixation compared to vaginal sacrospinous ligament fixation in the treatm...

Anti-HER-2-modified exosomes loaded with siRNA-STIL specifically target and inhibit the development and progression of gastric cancer

STIL is a key molecule influencing the proliferation and cell cycle of gastric cancer cells; however, STIL is also expressed in normal tissues. Therefore, designing a drug delivery system that targets gastric cancer cells is crucial for STIL-targeted therapy. In this study, we co...

Gut microbiota‑driven indole‑3‑propionic acid protects against sepsis‑associated encephalopathy via inhibiting BNIP3L ubiquitination and restoring BNIP3L‑dependent mitophagy as a potential molecular mechanism

Sepsis-associated encephalopathy (SAE) is a severe refractory neurological complication occurring in up to 70% sepsis patients with no targeted therapies. Gut microbiota-derived indole-3-propionic acid (IPA), a tryptophan metabolite, exerts neuroprotective effects, but its therap...

Spatial ecotype in tumor immune exclusion: from spatial architecture to therapeutic strategies

The tumor microenvironment (TME) exhibits widespread immunophenotypic heterogeneity. Based on the spatial immune contexture, tumor immune profiles can be classified as immune-inflamed, excluded, or desert. Immune-excluded tumors, a distinct tumor immune phenotype, are characteriz...

A Robust Mitochondria‐Targeted Photosensitizer Synergizes With Cisplatin Chemotherapy for Enhanced Antitumor Immunity

ABSTRACT Chemotherapy remains a major strategy for cancer treatment, with cisplatin widely used as a first‐line agent for diverse malignancies. Although cisplatin efficiently induces tumor cell death through DNA damage, its therapeutic efficacy is often limited by the development...