Ingham Institute

Patient perspectives on cardioprotective medication during breast cancer treatment

Cardiotoxicity remains a key concern of HER2-directed therapies, with no proven prevention strategies. The success of cardioprotective interventions will depend not only on efficacy, but on patient acceptability, an underexplored determinant of trial participation and clinical im...

Body Weight in Relation to the Effectiveness of Intravenous Alteplase in Acute Ischemic Stroke: The ENCHANTED Trial

BACKGROUND: The prognostic significance of body weight in patients receiving thrombolysis for acute ischemic stroke remains uncertain. This study aimed to determine whether body weight modifies the comparative effects of low- versus standard-dose intravenous alteplase and to eval...

Measurement of cervical cancer quality indicators using a population-based linked dataset in New South Wales, Australia

The aims of this study were to assess feasibility of measuring cervical cancer quality indicators (QIs) using a population-based linked dataset, assess the quality of care in the treatment of cervical cancer at a population level and to evaluate whether any sociodemographic varia...

DOES ROBOTIC-ASSISTED SURGERY OR FUNCTIONAL ALIGNMENT IMPROVE INTRAOPERATIVE BALANCE IN TOTAL KNEE ARTHROPLASTY? A SECONDARY ANALYSIS OF THE RASKAL TRIAL

Abstract Background This study assessed rates of imbalance in total knee arthroplasty (TKA) and its effect on patient-reported outcome measures (PROMs), comparing robotic-assisted surgery (RAS) versus computer-assisted surgery (CAS), and functional alignment (FA) versus mechanica...

Healthcare professionals’ practices, perceptions, and policy contexts of neonatal twin cobedding: a cross-sectional study

Background Twin cobedding is considered a developmental care practice in neonatal settings however little is known in relation to the practices and perceptions of neonatal healthcare professionals. Purpose To explore neonatal twin cobedding practices and healthcare professionals’...

Combining Implementation and Data Sciences to Accelerate Evidence Integration into Healthcare – ImpleMATE

Background The translation of research evidence into routine healthcare practice is often slow and inconsistent, even timely implementation can significantly improve patient outcomes. While implementation science offers strategies to close this gap, current approaches are frequen...

Clinicians' Perspectives and Experiences of Barriers, Enablers and Implementation of a Child and Adolescent Mental Health Crisis Service: A Qualitative Evaluation of the Safeguards Team Program

BACKGROUND: Presentations of children and young people (CYP) to Emergency Departments (ED) for acute mental health (MH) issues have increased globally and in Australia. The Safeguards Teams Program (STP) was implemented to provide acute, rapid response, recovery-focused, trauma-i...

Effectiveness of social skills interventions in young people aged 12 to 25 years with autism spectrum disorder: a systematic review and meta-analysis

Abstract Background While there are numerous social skills interventions (SSI) designed for pre-schoolers, the evidence supporting their effectiveness for adolescents and young adults remains limited. This study conducted a systematic review and meta-analysis to examine the avail...

HITH4HIPs: a feasibility trial of hospital in the home after hip fracture

In Australia, as in many other jurisdictions, people with low-trauma hip fractures often stay in hospital for extended periods, even when medically stable, increasing risk of hospital-related complications and increasing healthcare costs. In this context, we sought to determine t...