Industrial Development Bureau

Novel Coumarin Derivatives Containing Oxazole/Isoxazole/Pyrazole Groups as Antifungal Agents: Design, Synthesis, Quantitative Structure–Activity Relationships, and Preliminary Mechanistic Insights

Abstract Plant pathogenic fungi pose a significant threat to global crop productivity and food security. Herein, we report the design and synthesis of 55 coumarin–oxazole, −isoxazole, and −pyrazole hybrids as novel antifungal agents. Most derivatives exhibited notable potency, wi...

Systemic Sarcoidosis With Neurosarcoidosis and Obstructive Hydrocephalus: A Radiologic–Pathologic Case Report

Sarcoidosis is a systemic granulomatous disease characterized by non-caseating granulomas, most commonly affecting the lungs and intrathoracic lymph nodes. Central nervous system involvement (neurosarcoidosis) is rare but associated with significant morbidity and mortality, parti...