Indiana University Melvin and Bren Simon Comprehensive Cancer Center

Effect of implementation of a clinical checklist on the evaluation of constitutional mismatch repair deficiency in a neurofibromatosis clinic

BACKGROUND: Children with constitutional mismatch repair deficiency (CMMRD) require early and intensive cancer surveillance. Due to phenotypic overlap between CMMRD and neurofibromatosis type 1 (NF1), some children with CMMRD receive an incorrect diagnosis of NF1 and are inapprop...

Phase II study of CIMAvax EGF plus nivolumab in previously treated, immunotherapy-naïve advanced NSCLC

CIMAvax-EGF is a novel epidermal growth factor (EGF)-depleting therapy that induces the development of anti-EGF antibodies to clear free serum EGF from circulation. The primary objective of this single-arm phase II trial (NCT02955290) was to evaluate 12-month overall survival (OS...

Characterization of sex-dependent skeletal muscle alterations in the 3xTg Alzheimer’s disease mouse model

Alzheimer's disease (AD) is increasingly recognized as a systemic condition with effects beyond the central nervous system. Skeletal muscle dysfunction, including sarcopenia and reduced physical performance, is prevalent in AD patients, yet the underlying mechanisms remain poorly...

Body mass index at diagnosis, postdiagnosis change, and role of metabolic comorbidities in relation to survival in nonmetastatic renal cell carcinoma patients

Abstract Background Obesity is a recognized risk factor for renal cell carcinoma (RCC) incidence, but higher body mass index (BMI) measured at diagnosis has been paradoxically associated with improved survival. This study investigated whether postdiagnosis changes in BMI and meta...