Indiana University Health

Clinical Ethics Framework for Last‐Minute Pediatric Refusal of Anesthesia Induction

Induction of anesthesia is one of the most distressing moments for pediatric patients during their perioperative experience. They may consequently refuse induction at the last minute. Anesthesia providers are then placed in a challenging ethical dilemma: they must seek to gain th...

Induction Systemic Therapy Followed by Response-Adapted Consolidative Radiation in Locally Advanced Non-Melanoma Skin Cancer: A Retrospective Case Series

Background: There exists an unmet clinical need to define definitive management strategies for patients with locally advanced non-melanoma skin cancers (NMSC), particularly if not amenable to surgical resection. Methods: We retrospectively reviewed a case series of locally advanc...

Grief in Neurosurgery: Reframing Loss and Identity Through Lived Experience.

Grief is an under-recognized yet pervasive experience in neurosurgery, arising not only from the death of patients and loved ones but also from losses related to professional identity, health, and personal relationships. Despite its relevance, grief is often conflated with burnou...

Noise reduction interventions during golden hour admissions: A quality improvement project

Background Exposure to noxious noise increases stress levels and physiologic instability in premature infants and impacts to long-term negative repercussions on the neurodevelopment of this population and unintentionally counteracts the efforts of initial stabilization. Objective...

Ligand-Shell Softness Directs Symmetry Transitions in Nanotripod Superstructures

Abstract Low-symmetry, nonconvex nanocrystals offer access to superlattices with structural motifs that are difficult to realize from convex building blocks. Here, we show that polymer-grafted Gd2O3 nanotripods assemble into compact achiral and open chiral nanoporous superstructu...

Generating the symmetric group by three prefix reversals

The cubic pancake graphs are Cayley graphs over the symmetric group $\mathrm{Sym}_n$ generated by three prefix reversals. There is the following open problem: characterize all the sets of three prefix reversals that generate $\mathrm{Sym}_n$. As the largest prefix reversal of len...

Inducible chronic NAD deficiency in mice reveals multi-systemic phenotypical, metabolic, and transcriptional changes

Nicotinamide adenine dinucleotide (NAD) is a metabolic cofactor regulating energy metabolism, epigenetics, DNA repair, and signaling. Although NAD declines with vitamin B3 deficiency, disease, and aging, systemic consequences of chronic depletion remain unclear. Here, we characte...

Promoting Optimal Pediatric Readiness at US Trauma Centers: Understanding and Addressing Barriers

Children treated at facilities prepared to provide emergency pediatric care have improved outcomes, but access to pediatric-ready care remains inconsistent. A multidisciplinary spotlight session at the 2026 American College of Surgeons Committee on Trauma Annual Meeting examined...

Beyond Cys65: Redox Effector Factor-1 CRISPR-Engineered Cys93 and Cys99 Mutants Reveal Cooperative and Secondary Roles of Redox Signaling and Pancreatic Ductal Adenocarcinoma Progression

Aims: Apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1) is a multifunctional protein implicated in pancreatic ductal adenocarcinoma (PDAC) through its redox regulation of oncogenic transcription factors (TFs) such as hypoxia-inducible factor 1-alpha, nucle...

Proteogenomic profiling defines progression-associated biology in high-risk endometrial cancer

Patients with high-risk endometrial carcinoma (HR-EC) experience substantial mortality despite multimodality therapy, molecular classification and contemporary care. We determined whether proteomic tumor programs capture lethal risk beyond established clinical and genomic classif...

Less cooperative belowground plant mutualists negatively affect aboveground herbivore growth and survival

Abstract Resource mutualists like nitrogen (N)-fixing rhizobia can improve the nutrition of plants available to higher trophic levels. However, there is substantial intraspecific variation in mutualist quality. How this variation in mutualist quality affects higher trophic levels...

Reproducibility, Replicability, and Research Quality in Homogeneous Catalysis

Abstract Researchers from all sectors of homogeneous catalysis convened in response to concerns regarding reproducibility in science to analyze the issue and provide recommendations. In addition to an in-person workshop, the group engaged the broader homogeneous catalysis communi...

A Multistate Investigation of Serious Adverse Events, including Deaths, following Ceftriaxone Injections, September 2024–August 2025

BACKGROUND: Reports of ceftriaxone serious adverse events (SAEs), including deaths, from multiple jurisdictions during December 2024-January 2025 prompted a nationwide investigation to evaluate product safety, characterize SAEs, and assess for changes in baseline adverse event oc...

Community Health Workers' Perspectives on Career Advancement and Job Satisfaction: Indiana, March-August 2024.

. 2026;116(9): 1436-1444. https://doi.org/10.2105/AJPH.2026.308487).

Tibial Bone Shape Is Sport Dependent and More Symmetrical in High-Impact Athletes: A Cross-Sectional Study

Introduction: Multidirectional sports introduce unique forces to the tibia that potentially induce more symmetrical distribution of bone mass and lower bone stress injury risk, when compared to unidirectional sports. Purpose: To compare tibial shaft size, shape, and estimated str...

Perceived helpfulness of 56 treatment options in patients with chronic pain: a retrospective review

BACKGROUND: Chronic pain affects approximately 20% of US adults and often requires multiple treatment modalities. Although many therapies are available, less is known about which treatments patients perceive as helpful in real-world settings. METHODS: This retrospective cohort st...

‘Is something wrong with mine?’: exploring perceptions and implications of (un)representative anatomy illustrations among college students of colour

Exposure to representative imagery, or a lack thereof, has mental and physical health impacts including limiting or expanding a person's beliefs about possibilities for themselves and those with shared identities. We previously conducted a content analysis of 182 anatomical illus...

Physioxia Reprograms Glioblastoma Cells Enhancing Migration and Altering Therapeutic Sensitivity

Abstract Background/Objectives Glioblastoma is an aggressive primary brain tumor that develops within a chronically low-oxygen microenvironment, yet most preclinical studies are performed under atmospheric oxygen conditions that poorly reflect in vivo physiology. This study inves...

Investigating Preadmission Metrics and Early Academic Performance in Master of Physician Assistant Studies Students

INTRODUCTION: A growing number of student applications to graduate physician assistant (PA) programs has highlighted the need for effective selection of candidates. Much of the work in this area has focused on connecting student course grades and performance in the national board...

Effectiveness of RSV Prevention Strategies in US Infants: 2024–2025

OBJECTIVE: In 2023, 2 products, a long-acting monoclonal antibody (nirsevimab) and maternal respiratory syncytial virus (RSV) vaccination, were recommended in the United States to prevent severe RSV disease among infants in their first RSV season. Low uptake during the 2023 to 20...