Indian Institute of Technology Indore

Integrating Gaussian Accelerated Molecular Dynamics, β-Variational Autoencoders, and Markov State Models Reveals the Activation Landscape of FGFR3 Kinase

Abstract Fibroblast growth factor receptor 3 (FGFR3) kinase plays a crucial role in cellular differentiation, proliferation, and skeletal development. Activation of the kinase domain through phosphorylation regulates the downstream signaling cascades, and its dysregulation leads...

Orbital Coupling Engineering through P-Block Metal Doping in NiFe Layered Double Hydroxides for Enhanced Anion-Exchange Membrane Water Electrolysis

Abstract The oxygen evolution reaction (OER) remains a major kinetic bottleneck in anodic water splitting because of sluggish adsorption and desorption kinetics of O-containing intermediates. Optimizing the adsorption strength of various O-containing intermediates in accordance w...

Regioselective Aminomethylation and Benzylation of N -Heterocycles via Controllable Cleavage of Triazinanes under Ambient Conditions

A site-selective reaction for the aminomethylation of imidazoheterocycles is developed using photoredox catalysis under mild conditions. A complementary metal free HFIP promoted reaction is also developed which gives corresponding anilines in good yields. Metal free conditions, s...

Rongalite-Promoted One-Pot Reductive Cyclization Strategy for the Construction of Pyrrolo[1,2-α]quinoxalines from 1-(2-Nitrophenyl)pyrroles

Abstract A transition-metal-free strategy for the synthesis of pyrrolo[1,2-α]quinoxalines and 7-methylindolo[1,2-α]quinoxaline from 1-(2-nitrophenyl)-1H-pyrrole or 3-methyl-1-(2-nitrophenyl)-1H-indole using rongalite have been developed. In this transformation, rongalite serves a...

Recombinant Organophosphorus Acid Anhydrolase and Silver Nanoparticles Immobilized Electrospun Nanofibers for Biocatalysis and Antimicrobial Functions

Abstract Organophosphate compounds (OPs) are widely used pesticides among all existing pesticide categories, yet their toxicity and persistence pose significant environmental and health challenges. Nearly one-third of global pesticide poisoning cases occur in a single country, hi...

Benzothiazole-Based Smart Luminescent Materials: Synthesis, Functionalization, Mechanochromism, and Acidochromism

Abstract Stimuli-responsive luminescent organic materials have attracted significant attention due to their dynamic optical response toward external stimuli and their potential applications in advanced technologies. Among various heterocyclic frameworks explored for such applicat...

Measurements of the production of W$$^{\pm }$$ and Z$$^0$$ bosons in pp collisions at $$\sqrt{s} = 13$$ TeV

Abstract Measurements of the production of the W $$^{\pm }$$ ± and Z $$^0$$ 0 bosons at midrapidity in pp collisions at $$\sqrt{s} = 13$$ s = 13 TeV with ALICE at the Large Hadron Collider (LHC) are presented. The W $$^{\pm }$$ ± and Z $$^0$$ 0 bosons are detected via their (di)e...

Rock glaciers in the Hindu Kush Himalaya: A regional synthesis

Rock glaciers are cryospheric landforms in high-mountain regions and indicators of permafrost occurrence and change under accelerating climate warming. This review synthesizes 67 peer-reviewed studies on rock glaciers across the Hindu Kush Himalaya (HKH) published between 1970 an...

Odd-Nuclearity in Homologous Series of Ni-Tiara Clusters Unlocking Near-Unity NH3 Selectivity in Electrochemical Nitrate Reduction

Abstract Electrochemical nitrate reduction to ammonia offers a sustainable alternative to the Haber-Bosch process while mitigating nitrate pollution. However, the development of nitrate reduction reaction catalysts is hindered by ambiguous active-site structures, poorly understoo...

Machine Learning Framework with Posthoc Explainability for Predicting the Strength of Mechanochemically Activated Geopolymer Paste

Abstract Geopolymers offer a low-carbon alternative to ordinary portland cement (OPC); yet their industrial adoption is hindered by complex multivariate design spaces exceeding 10 6 possible formulations and reliance on empirical optimization. This study integrates mechanochemica...

Reducing turnaround time to improve the performance of the quality control laboratory: A case study of the pharmaceutical industry

The quality control laboratory of any industry must ensure the quality of products to meet the regulatory compliances. However, the quality control in healthcare industry and pharmaceutical firms are highly relevant as its products’ quality directly impacts the human health. Henc...

Modified residual network architecture for early-stage piston-cylinder wear detection in hydraulic axial piston pumps

Axial piston pumps are widely used in aerospace and construction machinery because of their high volumetric efficiency, compact design, and high-pressure, variable-flow capability. However, their closely mating components are susceptible to wear, making early detection essential....

Geometry-Encoded Droplet Evaporation on Rectangular Micropillared Surfaces: From Wetting-State Transitions to Programmable Colloidal Deposit Morphology

Abstract Evaporation-driven deposition of colloidal particles on microtextured surfaces offers a versatile route to material patterning for technologically critical processes, including precision inkjet printing, functional coating, biosensing, and directed colloidal self-assembl...

Extended Appendix: From X-rays to High-Energy Gamma-rays: A Comprehensive Multi-Wavelength Study of Early Gamma-Ray Burst Afterglows

This extended abstract provides additional details, figures, tables, and results supporting the analysis presented in the main manuscript titled "From X-rays to High-Energy Gamma-rays: A Comprehensive Multi-Wavelength Study of Early Gamma-Ray Burst Afterglows". We present the com...

Deterritorialised diaspora: a literary testimony of uprooted migrants in The Boat People

The Global South has long been at the epicentre of forced migration and structural violence. Literary narratives emerging from these contexts challenge dominant Northern discourses by articulating the lived experiences of deterritorialisation. This article addresses the theoretic...

A Novel Mechanistic Route to the Formation of an Internal Aldimine between Pyridoxal 5′-Phosphate and Ornithine Decarboxylase Enzyme at Its Active Site

Abstract Pyridoxal 5′-phosphate (PLP) functions as a vital cofactor in numerous biochemical processes. To perform its role as a cofactor, PLP has to first form a Schiff base complex with the enzyme, known as the internal aldimine, which is an important step for the function of al...

(Methyl)thianthrenium Salt Assisted Metal-Free Protocol for the Synthesis of N- Sulfonyl Formamidines

Abstract A new strategy for the rapid and efficient synthesis of N-sulfonyl formamidines has been developed through the activation of N,N-dimethylformamide (DMF), assisted by (Methyl)thianthrenium salt under ambient conditions. The protocol offers a metal and oxidant-free process...

Lac cultivation and rural transformation: an empirical study on income generation and employment among tribal households in Jharkhand

Purpose Lac, a natural resin secreted by Kerria lacca, is an ecologically sustainable non-timber forest product with substantial yet under-utilised economic and employment potential for India's tribal communities. This study empirically examines the determinants of income and emp...

Donor‐Controlled Intramolecular Charge Transfer in Multi‐Modular Push‐Pull Conjugates Containing Competing Electron Acceptors

ABSTRACT The superior electron‐accepting behavior of fullerene (C 60 ), even in the presence of strong electron acceptor entities, is demonstrated in a series of multi‐modular push‐pull systems carrying a donor, phenothiazine, and C 60 , coupled with strong electron acceptors, te...

Plasma Turbulence in the Lunar Environment Across Solar Wind and Magnetotail Conditions: Observations From Chandrayaan‐2 Radio Science Experiment

Abstract The Moon's transit between the solar wind and Earth's magnetotail exposes the near‐lunar environment to large and rapid variations in plasma density and flow structure. Two‐way coherent S‐band radio occultation measurements from Chandrayaan‐2 were used to quantify electr...