Indian Institute of Technology Goa

A validated IL1β-induced caprine ex vivo early osteoarthritis model reveals disease-modifying efficacy of TC-S 7009 via HIF-2α inhibition

Osteoarthritis (OA) is a debilitating multifactorial joint disease lacking effective disease-modifying OA drugs (DMOADs). High failure rates for clinical trials in OA could be due to inadequate screening approaches that rely on single target strategies and late-stage disease mode...

Biochemical Investigation of PumG, a Key Pyridoxal 5′-Phosphate (PLP)-Dependent Aminotransferase Involved in Pseudouridimycin Biosynthesis

Abstract Pyridoxal 5′-phosphate (PLP)-dependent aminotransferases play a central role in nucleoside antibiotic biosynthesis, where they catalyze the conversion of ribose-derived aldehyde intermediates into aminonucleosides by introducing critical amino functional groups. Despite...

Limits at Infinity for Functions in Fractional Sobolev Spaces

Abstract We establish optimal results on limits at infinity for functions in fractional Sobolev spaces.