Indian Institute of Science Education and Research, Bhopal

A CTCF-LDHB axis converts nuclear lactate availability into an H3K18 acylation switch that directs alternative splicing in hypoxic breast cancer

Lactate accumulating in hypoxic tumours lactylates histones, coupling metabolic state to chromatin. Why it differs between tumours of comparable glycolytic rate has remained unresolved. Here we show that nuclear, rather than total intracellular, lactate availability determines hi...

circEPSTI1 regulates miR-942-5p–SERPINE1–AKT1 signaling axis to enhance dengue infection and is suppressed by Tiplaxtinin

Circular RNAs (circRNAs) have recently been identified as crucial regulators of gene expression in various diseases. Their role in dengue remains unexplored. In this study, circEPSTI1 induction was observed in peripheral blood mononuclear cells and plasma of dengue patients. The...

Mantle deformation patterns beneath the Central India Tectonic Zone: evidence from SK(K)S splitting measurements in the Satpura Gondwana Basin and adjacent areas

Abstract. This study presents shear wave splitting (SWS) estimates for core-refracted SK(K)S phases utilizing data from nine seismic stations in the Central Indian Tectonic Zone (CITZ) that were temporarily operational between July 2023 and July 2025. The CITZ was formed during t...

Influence of Natural Seawater Electrolyte on CO2 Electroreduction on Transition Metal Phosphate Electrocatalysts and Suppression of Cathode Scaling with Buffering Action

Abstract Carbon dioxide electroreduction (CO2 ER) provides a promising approach to produce renewable fuels; however, achieving selective formation of higher-value C1+ products is still a challenge. In this work, we explored whether untreated natural seawater can modify the electr...

Functionalized Graphene/PAN Hollow Fiber Mixed Matrix Membranes: Effects of Surface Functionality and Loading on CO2/N2 Separation

Abstract The development of high-performance hollow fiber mixed matrix membranes (HFMMMs) for post-combustion carbon capture requires rational design of nanofillers that simultaneously enhance CO2 transport, molecular selectivity, and operational stability. In this study, polyacr...

Emergent coherent-incoherent phonon crossover enables ultralow lattice thermal conductivity in 3D double perovskite

The interplay between coherent (wave-like) and incoherent (particle-like) phonon transport is central to heat conduction, yet experimental evidence of their crossover in bulk three-dimensional (3D) crystals remains scarce. Here, we report intrinsically ultralow lattice thermal co...

Coupling the Spin State Switching and CO2 Adsorption Operating at Different Temperatures in a Breathing Metal–Organic Framework

Gas-responsive magnetic response arising from spin-crossover (SCO) phenomena is rare yet highly attractive for molecular sensing and spintronics. However, it remains unclear how gas uptake influences SCO behaviour when the two phenomena occur in separate temperature regimes. Here...

Flash Communication: Transfer Hydrogenation of Formic Acid to Methanol

Abstract An alternative route for the reductive conversion of formic acid to methanol via transfer hydrogenation (FATH) reaction is demonstrated. The FATH reaction is catalyzed by “N-heterocyclic carbene–pyridine–benzimidazolato”-based CNN pincer ligand-bound Ru complexes employi...

Dualizing Involutions on the n‐Fold Metaplectic Cover of GL(2)

ABSTRACT Let be a non‐Archimedean local field of characteristic zero and . Let be a positive integer and be the ‐fold metaplectic cover of . Let be an irreducible smooth representation of and be the contragredient of . Let be an involutive anti‐automorphism of satisfying . In thi...

Mass‐Conserving LSTM With Dual States for Streamflow Prediction: Separating Quickflow and Slow Storage

Abstract We introduce a Mass‐Conserving Long Short‐Term Memory with Dual States (MC‐LSTM‐DS) with the intention of separating short‐ and long‐term memory for predicting streamflow. It enforces water balance through a new partition gate on precipitation. We benchmark MC‐LSTM‐DS ag...

A targeted search for fast radio bursts from magnetars in elliptical galaxies

Abstract Motivated by predictions that globular clusters associated with nearby giant elliptical galaxies are prime environments for detecting fast radio bursts (FRBs) from magnetars, we report on a targeted high-sensitivity search across five local massive elliptical galaxies. W...

Spatiotemporal dynamics of contiguous daytime, nighttime, and compound heatwaves across India

This repository contains R and Python codes for identifying daytime, nighttime, and compound heatwaves; converting heatwave data into three-dimensional arrays; and performing 26-connectivity Connected Component (CC3D) analysis to identify contiguous spatiotemporal heatwave events...

Spatiotemporal dynamics of contiguous daytime, nighttime, and compound heatwaves across India

This repository contains R and Python codes for identifying daytime, nighttime, and compound heatwaves; converting heatwave data into three-dimensional arrays; and performing 26-connectivity Connected Component (CC3D) analysis to identify contiguous spatiotemporal heatwave events...

Interpretable machine learning reveals contrasting drivers of streamflow droughts in regulated and natural river systems

This study investigates the spatial, temporal, and process-based dynamics of streamflow droughts across the Godavari River basin using daily discharge records from multiple gauging stations. A multivariate framework integrating drought duration, intensity, and deficit was employe...

A Small Molecule Substrate Mimic to Inhibit Bacterial Hsp70 Chaperone Function

Given the rapid spread of antibiotic resistance worldwide, it is imperative to develop new strategies against pathogenic bacteria. Here, we report a small‐molecule inhibitor of bacterial heat shock protein 70 (Hsp70), called DnaK, a central component of the bacterial protein chap...

Zooming in on ‘bi-large’ neutrino mixing with the first JUNO results

Abstract The leptonic mixing matrix is examined within bi-large mixing patterns and confronted with the latest results announced by the Jiangmen Underground Neutrino Observatory (JUNO). We analyze the viability of bi-large mixing schemes and assess JUNO’s ability to test neutrino...

Moiré‐Induced Symmetry Breaking of Charge Order in van der Waals Heterostructures

ABSTRACT Layered materials that stack different lattice symmetries are rare in nature. Misfit layered chalcogenides, which combine square and hexagonal lattices of rocksalt monochalcogenides and transition‐metal dichalcogenides, provide a platform to explore how incommensurabilit...

Social (in)security and social policy for gig workers in South Asia

Over the last decade, digital worker platforms and the digital economy have become integral parts of labour worldwide, including in South Asian countries. Gig workers often experience job insecurity, low wages, long working hours, and harsh working conditions, which make their li...