Indian Institute of Science Bangalore

Urolithin A mitigates behavioural and synaptic deficits associated with epilepsy

Abstract The persistence of drug-resistant epilepsy highlights the need for new therapeutic interventions that target novel mechanisms with homeostatic regulations while minimizing side effects. Slow-acting drugs, particularly small molecules of natural origin with anti-epileptog...

A comprehensive assessment of temporal limit and efficacy of Budyko framework in capturing various climate change and human intervention scenarios using a controlled synthetic environment over ten Indian basins

Study Region 10 Indian basins Study Focus The traditional Budyko framework (TBF) is a simple model developed for studying the long-term mean behaviour of natural catchments, assuming negligible storage change. However, efficacy of the framework under climate change is still debat...

Hybridizing MXenes with MOFs: a pathway to smart sensing platforms and efficient water remediation

The need for the efficient platforms creating innovative applications in the field of sensing, wastewater treatment, and industrial safety has resulted in the development of novel and advanced hybrid materials with unique morphological structures and superior performance. Hybrid...

Bifurcation-Based Quadrotor Guidance for Circular Inspection Modes

This paper presents a new guidance method for a quadrotor uncrewed aerial vehicle to perform standoff inspection from specific viewpoints arranged along a circular periphery surrounding a structure. The proposed approach leverages a bifurcation-theory-based framework to realize m...

Pollutant-induced changes in fish pigmentation and spatial patterns

Abstract Pigmentation abnormalities, ranging from hypo- to hyperpigmentation, can serve as biomarkers of developmental disruption in fish exposed to environmental contaminants. However, the mechanistic pathways underlying these alterations remain poorly understood. Studies have s...

Implementation of a colorimetry-based urinary biomarker screening system for early UTI risk detection

Urinary Tract Infections (UTIs) are a significant health concern, particularly among infants, elderly individuals, and bedridden patients, where delayed detection can lead to severe complications. This paper presents a colorimetry-based smart diaper system for the early, noninvas...

From Discrete to Dense: Explorations in the Moduli Space of Triangles

SummaryThe moduli space of triangles is a two-dimensional space that records triangle shapes in the plane, considered up to similarity. We study the subset corresponding to lattice triangles, which are triangles whose vertices have integer coordinates. We prove that this subset i...

Intrinsic Excitability of Rat Hippocampal Granule Cells Increases Along the Dorsal‐to‐Ventral Axis

ABSTRACT The dentate gyrus (DG) of the hippocampus exhibits striking anatomical and functional heterogeneity along its dorsoventral axis, yet the intrinsic electrophysiological diversity of its principal excitatory neurons, the granule cells, across the dorsoventral axis remains...

Implications of key uncertainties in long-term land use emissions for India's net-zero future — an integrated modelling assessment

This deposit contains the datasets required to interpret, replicate and build upon the study "Implications of key uncertainties in long-term land use emissions for India's net-zero future — an integrated modelling assessment," which uses the Global Change Analysis Model (GCAM v6)...

Living helices in fluctuating polymer chains: Cooperative nucleation and dynamics

Helical segments in polymer chains are often transient, finite, and dynamically evolving, yet their origin and stability remain incompletely understood. Here, we develop a minimal coarse-grained statistical-mechanical theory that explains how such “living helices” emerge in fluct...

Influence of imposter phenomenon on emotion regulation strategies among young adults: A cross-sectional study

Abstract Background: Imposter phenomenon (IP) significantly influences mental health, often leading to increased levels of stress and anxiety, along with behavioral repercussions, which are harmful to the self, thereby affecting performance and routine life. It refers to an inter...

A matrix-targeting enzyme and an engineered bioactive gauze enable resistance-agnostic antibiofilm wound care

The development of biocompatible strategies that dismantle biofilm architecture without exerting bactericidal pressure represents a major challenge in translational biotechnology and materials engineering. Here, we present a matrix-targeted enzymatic strategy for biofilm control...