Independent Sector

The locus coeruleus gateway hypothesis: Noradrenergic integrity as a candidate determinant of amyloid-β clearance efficiency in anti-amyloid immunotherapy for Alzheimer's disease

) status, or tau burden-leave largely unexplained. We propose that a systematically unmeasured upstream variable contributes to this variability: the structural integrity of the locus coeruleus (LC), the principal source of brain norepinephrine (NE), framed as a candidate determi...

HEPE Lyapunov V(s)=0: First Hardware-Enforced AI Governance Certificate with Topological Bypass Impossibility

We introduce the HEPE (Hardware-Emergent Policy Enforcement) Lyapunov certificate V(s), a scalar function over the 16-state hardware governance space {0,1}^4 that provably reaches zero exactly when all four hardware enforcement layers are simultaneously active. We prove that V(s)...