Independent Sector

Co-creating culturally safe primary care for whānau Māori with cancer: a qualitative case study of systems change in general practice

INTRODUCTION: Māori experience later cancer diagnosis and poorer cancer outcomes than non-Māori. Although consultation-level cultural safety frameworks exist, less is known about embedding cultural safety across general practice to improve outcomes, guided by whānau (family) voic...

The Essence of Life and the Brain-Constructed World: Consciousness, Nature, and the Experience of Liberation from the Brain-Constructed World

Human beings do not experience the world directly as it is. At the level of human experience, what we call the world emerges through the interaction of reality with sensory systems, memory, emotion, survival mechanisms, language, judgment, and the brain’s predictive processes. Th...

Existential Clinical Psychology—Subjectivity, Meaning, and Action

This preprint presents a theoretical framework for existential clinical psychology organized around subjectivity, meaning, and action. It distinguishes symptom control from the restoration of existential agency and proposes the concept of adaptive finite freedom: freedom belongs...

Exploring the Impact of Epstein-Barr Virus and Cytomegalovirus Reactivation on COVID-19 Severity and Host Immune Response

Background: Reactivation of latent Epstein-Barr virus and cytomegalovirus is commonly observed among critically ill patients presenting with severe COVID-19. Methods: Retrospective cohort study comprising adult patients admitted to a simple hospital with COVID-19 infection from M...

GeoVac (The Geometric Vacuum): Structurally Sparse Qubit Hamiltonians and the Discrete Spectral Triple

GeoVac is a spectral-graph-theory framework for computational quantum chemistry and mathematical physics. The discrete graph Laplacian on the three-sphere S^3 is mathematically equivalent to the Schrodinger equation via Fock's 1935 conformal projection (Paper 7, 18/18 symbolic pr...

Molecular Glue Degraders in Early Development for Cancer Therapy

Molecular glue degraders are an emerging class of small molecule allosteric modulators that induce or stabilize protein-protein interactions, enabling targeted degradation of previously intractable proteins. By redirecting E3 ligases to recognize neosubstrates, proteins that are...

The locus coeruleus gateway hypothesis: Noradrenergic integrity as a candidate determinant of amyloid-β clearance efficiency in anti-amyloid immunotherapy for Alzheimer's disease

) status, or tau burden-leave largely unexplained. We propose that a systematically unmeasured upstream variable contributes to this variability: the structural integrity of the locus coeruleus (LC), the principal source of brain norepinephrine (NE), framed as a candidate determi...

HEPE Lyapunov V(s)=0: First Hardware-Enforced AI Governance Certificate with Topological Bypass Impossibility

We introduce the HEPE (Hardware-Emergent Policy Enforcement) Lyapunov certificate V(s), a scalar function over the 16-state hardware governance space {0,1}^4 that provably reaches zero exactly when all four hardware enforcement layers are simultaneously active. We prove that V(s)...