Imam Khomeini Hospital

Evaluation of changes in quality of life, life satisfaction, and anxiety following in-person and virtual dignity therapy in patients with heart failure: a quasi-experimental controlled study

Dignity therapy is a life review intervention that can help reduce existential and spiritual distress in patients with heart failure. However, there is limited evidence comparing the two delivery modes (in-person and virtual) of this intervention. This study aimed to evaluate cha...

Coated or chewable Aspirin and a hybrid air pollution mitigation strategy in patients with atherosclerotic disease: Rationale and Design of the COATED-AIR Randomized Trial.

BACKGROUND: Although enteric-coated aspirin is widely used instead of chewable formulations in patients with atherosclerotic cardiovascular diseases (ASCVD), its effects on cardiovascular and gastrointestinal outcomes remain uncertain. Separately, air pollution is a driver of car...

Feedback loops as a core driver: rethinking organizational readiness for knowledge translation in Iranian medical universities

Bridging the gap between research evidence and healthcare decision-making, knowledge translation (KT) is a critical process. However, despite advances in research production, many universities in low- and middle-income countries face significant challenges in implementing KT due...

Evaluating the Role of Exosome Therapy in Reproductive Aging:A Narrative Review of Recent Advancements.

INTRODUCTION: Exosome therapy shows promise as a non-hormonal treatment to restore ovarian function and combat reproductive aging. This review aims to explore recent advances, mechanisms, and clinical potential of exosome therapy in reproductive aging. METHODS: This narrative rev...

Effect of a multilevel blended intervention based on social cognitive theory on fruit and vegetable consumption in students

Inadequate fruit and vegetable (F&V) consumption among adolescents remains a critical global public health challenge. This cluster-randomized controlled trial evaluated the effectiveness of a SCT-based multilevel blended intervention in increasing F&V consumption-frequency scores...

The Gut-Brain Axis in Neurodegeneration: Mechanistic Links Between Dysbiosis and Neuropathology.

Background & Objective: The gut-brain axis is essentially a two-way communication system that physically connects the brain and the intestinal tract. The connection is mediated through a series of pathways, including neural, endocrine, and immune pathways. Gut dysbiosis, which is...

Assessing the concordance between ultrasonography and MRI for evaluation of structural features in knee osteoarthritis: a prospective cross-sectional study

Abstract Background Knee osteoarthritis (KOA) is a prevalent degenerative joint disease characterized by progressive structural and functional impairment. While magnetic resonance imaging (MRI) is regarded as the reference standard for assessing joint pathology, ultrasonography (...

Situation analysis of breast cancer screening in Iran: a mixed-methods study

Breast cancer is the leading cause of cancer death among Iranian women, yet national screening remains opportunistic and unevenly implemented. This study assessed Iran’s breast cancer screening system to identify gaps and opportunities for establishing an organized, population-ba...

Beyond guideline deviation: understanding surgical antibiotic prophylaxis nonadherence in Iranian surgical practice using the theoretical domains framework

Surgical antibiotic prophylaxis (SAP) is essential for preventing surgical site infections, yet inappropriate perioperative antibiotic use remains a persistent stewardship challenge. Although SAP non-adherence is well documented, the behavioral and organizational mechanisms susta...

Establishing MRI-based thresholds for corpus callosum in children aged 1–6: a comparison of typical development and cerebral palsy-associated morphometry

The corpus callosum (CC) is central to neurodevelopment, and morphometric abnormalities are linked to atypical development. This study aimed to establish age-dependent and age-independent MRI-based cutoffs defining normative CC morphology in children aged 1–6 years, distinguishin...

Fatal invasive pulmonary aspergillosis caused by Aspergillus texensis: first documented human infection

<title>Abstract</title> Background Invasive Aspergillosis (IA) is a life-threatening infection in immunocompromised patients. Although <italic>Aspergillus fumigatus</italic> predominates, rare and cryptic species are increasingly recognized due to advances in molecular diagnostic...

Spontaneous pneumomediastinum secondary to profound weight loss and malnutrition: a case report and review of malnutrition as a primary etiology

Spontaneous pneumomediastinum (SPM) is a rare but significant complication of anorexia nervosa (AN). While historically linked to Valsalva maneuvers, a growing body of evidence implicates severe malnutrition as an associated risk factor, challenging traditional etiologic models....

A rare presentation of metastatic thymic carcinoma mimicking pheochromocytoma and Von Hippel–Lindau syndrome: a case report

Metastatic thymic carcinoma is a rare and aggressive malignancy that may present with atypical clinical and biochemical features, posing significant diagnostic challenges. We report the first documented case of metastatic thymic carcinoma mimicking both pheochromocytoma and Von H...

Spatial patterns and factors associated with suicide death among individuals with suicide attempts in northern Iran

Suicide is a major global health concern causing over 720,000 annual deaths, with most occurring in low- and middle-income countries. Official reports in Iran demonstrate increasing and regionally varied patterns, with distinctly elevated risk levels observed in certain province....