Imam Abdulrahman Al Faisal Hospital

Spatially-integrated Ancestry Polygenic Risk Mapping for Diabetes: A Geographic-adjusted Genetic Scoring Framework

Abstract Background: Conventional polygenic risk scores (PRSs) often fail to capture geographic and ancestry-specific variation, limiting their predictive accuracy in admixed and globally diverse populations. This study aims to develop a spatially-aware PRS (SA-PRS) framework tha...