IBM Research - Thomas J. Watson Research Center

Brain signatures of body mass index predict cardiometabolic and respiratory disease status

Abstract Despite advances in brain biomarkers using neural networks, the effects of body mass on brain structure have been neglected, particularly in connection with noncommunicable diseases. Here, we isolated brain biomarkers of body mass index (BMI) and evaluated their associat...

Sakura: An Approach for Generating Complex Tests from Natural Language Test Descriptions

Testing is a core activity in software development, and research on its automation has spanned several decades. Most existing approaches focus on generating unit tests for individual methods, validating isolated API endpoints, or targeting user interface (UI) layers. However, for...

Order Parameter Discovery for Quantum Many-Body Systems

Quantum phase transitions reveal deep insights into the behavior of many-body quantum systems, but identifying these transitions without prior knowledge of order parameters remains a significant challenge. In this work, we introduce a method for constructing phase diagrams using...

The Python simulations of chemistry framework: 10 years of an open-source quantum chemistry project

Over the past decade, the Python-based Simulations of Chemistry Framework (PySCF) has developed into a widely used open-source platform for electronic-structure theory and quantum chemical method development. This article reviews the major advances since the previous overview in...

Understanding sidewall passivation composition of single-step non-Bosch processes for deep Si etch using alternative gas mixtures

Bosch processes involving C4F8 and SF6 have been conventionally used for through-silicon via etch. However, given the high global warming potential of C4F8 and the importance of high aspect-ratio deep-Si etch processes for packaging applications in next-generation technology node...

Intra-tumoral epigenetic heterogeneity and aberrant molecular clocks in hepatocellular carcinoma

There is limited understanding of the epigenetic drivers of tumor evolution in hepatocellular carcinoma (HCC). Here we characterize the epigenetic contribution of methylation to intra-tumoral heterogeneity (mITH) using regional enhanced reduced-representation bisulfite sequencing...

Analysis of Power Iteration Algorithm With Partially Observed Matrix‐Vector Products

ABSTRACT We consider the problem of computing the dominant eigenvector of a symmetric matrix via the power iteration algorithm subject to constraints in the computation of matrix‐vector products. In particular, we focus on scenarios where the entries of matrix‐vector products wit...

A foundation model for sleep-based risk stratification and clinical outcomes

Abstract Clinical sleep studies capture multiple physiologic signals, yet interpretation is often reduced to single summary measures of limited prognostic value, such as the apnea–hypopnea index. We present a foundation model that learns rich representations of sleep physiology f...