Iaso Children’s Hospital

Early-Life Nutrition: The Interplay of Nutritional, Microbial, Genetic, and Environmental Factors in Food Allergy Development and Prevention

Background: Food allergy is an important health concern, particularly during infancy and early childhood. Its development reflects complex interactions between genetic susceptibility and early-life nutritional, microbial, epithelial, immunological, and environmental factors. Obje...

Targeting SUV4–20H2-mediated H4K20 methylation restrains growth and migration in pediatric high-grade astrocytomas

Pediatric astrocytomas are characterized by increased molecular and clinical heterogeneity with epigenetic alterations contributing to aggressiveness and therapy resistance. The repressive histone mark H4K20 trimethylation (H4K20me3) and the methyltransferase SUV4–20H2 (KMT5C) ar...