Hyogo Medical University

Adverse impact of deletion of the chromosome 6 on clinical outcomes after allogeneic hematopoietic transplantation

Graft-versus-leukemia (GVL) effect is mainly mediated by alloreactive T and NK cells through human leukocyte antigen (HLA). Although most HLA genes are located on the short arm of chromosome 6, the clinical significance of deletion of the short arm of chromosome 6 (del6p) which c...

Protocol for a phase I/II, open-label, single-arm trial of autologous chemically induced liver progenitor (CLiP) cell transplantation in patients with decompensated cirrhosis

Introduction Decompensated cirrhosis is associated with a poor prognosis and limited therapeutic options for patients who are not candidates for liver transplantation. Although various cell-based regenerative therapies have been investigated, their clinical benefits are limited....

Projected prevalence of hypertension and untreated/uncontrolled hypertension in Japan through 2040

Accurate projections of future hypertension prevalence are essential for planning effective public health strategies to prevent cardiovascular mortality. This study aimed to project the future prevalence of hypertension in Japan through 2040. Prevalence estimates of hypertension...

Comparison of PMAneo and RAPID in acute ischemic stroke: agreement in CT perfusion analysis and DEFUSE 3 imaging eligibility

Abstract Purpose Automated computed tomography perfusion (CTP) analysis plays a key role in triaging acute ischemic stroke (AIS). This study aimed to evaluate the agreement of PMAneo compared with RAPID in a multicenter setting. Materials and methods We retrospectively reviewed 9...

Remission Trajectories During Low-Intensity Cognitive Behavioural Therapy for Obsessive–Compulsive Disorder: A 2-Year Naturalistic Follow-Up Study

Background and Objectives: Cognitive-behavioural therapy (CBT) for obsessive–compulsive disorder (OCD) has primarily been evaluated in short-term, high-intensity treatment protocols. However, remission trajectories during low-intensity CBT (LiCBT) delivered in routine clinical pr...

Long-term immunoprophylaxis by TLR9 ligand mediates macrophage-ILC cross-talk against respiratory viral infection

Rapid development of host immunity is critical during the emergence of viral outbreaks when vaccines are not yet available. Here, we demonstrate that CpG oligodeoxynucleotide-schizophyllan complex (K3-SPG) induces antigen-independent, long-term protection against lethal respirato...

Mechanisms of Associational Effects of Sika Deer Browsing: Relationships Between Plant Nutrients and Foraging Behavior

ABSTRACT The susceptibility of plants to ungulate herbivory is affected by herbivore foraging selection, which is influenced by neighboring plants within a patch (associational effect). However, the role of plant nutritional characteristics in herbivore foraging behavior, which g...

Cesarean delivery and overweight at 6 years of age: a prospective cohort analysis of the Japan Environment and Children’s Study

Abstract Cesarean delivery (CD) has been suggested as a potential risk factor for childhood overweight and obesity; however, evidence beyond early childhood remains inconsistent. We examined the association between CD and childhood overweight at age 6 years and explored early lif...

Cardiovascular complications in adults with clinically diagnosed osteogenesis imperfecta: A cross-sectional study with echocardiography and magnetic resonance imaging

Background: Osteogenesis imperfecta (OI) is a congenital bone fragility disorder, in which 90% of patients have abnormalities in type 1 collagen. Cardiovascular complications, including valvular heart disease and vascular aneurysms, are reportedly comorbid with this disease. Meth...

Diagnostic accuracy of 18F-PSMA-1007 PET/CT and bone scintigraphy for detecting bone metastases in prostate cancer

Abstract Objective The performance of 18 F-labeled prostate-specific membrane antigen ( 18 F-PSMA-1007) positron emission tomography/computed tomography (PET/CT) and bone scintigraphy (BS) for detecting bone metastases in prostate cancer patients was compared. Materials and metho...

Repeated Response to Daratumumab in Refractory MGUS‐Associated Pure Red Cell Aplasia Persisting After Allogeneic Transplantation: A Case Report

ABSTRACT Pure red cell aplasia (PRCA) is usually managed as a disorder driven predominantly by cellular immune mechanisms, but plasma cell‐directed therapy may be relevant in selected cases associated with monoclonal gammopathy. We report a case of refractory PRCA associated with...

Management and Outcomes of Cardiac Sarcoidosis: Insights From the Nationwide MYSTICS Registry

BACKGROUND: Cardiac sarcoidosis (CS) may lead to serious outcomes, but large-scale data are lacking because of its rarity, diagnostic uncertainty, and heterogeneous clinical presentations. Actual management and outcomes, including recurrence, are not well understood. This study a...

Prediction and assessment of response to anti-inflammatory therapy in medication-related osteonecrosis of the jaw using harmonized quantitative bone SPECT/CT: A multicenter study.

OBJECTIVE: The utility of harmonized quantitative bone single-photon emission computed tomography/computed tomography (SPECT/CT) parameters for prediction and assessment of treatment response to anti-inflammatory therapy for medication-related osteonecrosis of the jaw (MRONJ) was...

Prognostic clinical indicators in patients with metastatic castration-resistant prostate cancer treated with radium-223 plus enzalutamide: Data from patients in J-RAP-BSI trial.

OBJECTIVE: Ra) and enzalutamide combination therapy. SUBJECTS AND METHODS: Ra and enzalutamide at 14 hospitals and had pretreatment bone scintigraphy findings available for analysis. Associations of overall survival (OS) with clinicopathological factors, including Eastern Coopera...

Postoperative Swallowing Function After Minimally Invasive Esophagectomy Assessed by Videofluoroscopic Swallowing Study and Cough Test

Background/Aim: Postoperative dysphagia is a common and clinically important complication after esophagectomy; however, perioperative changes in swallowing function and airway-protective reflexes have not been well characterized. Here, we aimed to evaluate perioperative changes i...

Prognostic Impact of Circumferential Resection Margin in Minimally Invasive Surgery for Locally Advanced Rectal Cancer: A Multicenter Prospective Study

ABSTRACT Aim Circumferential resection margin (CRM) status is a well‐established prognostic factor in rectal cancer surgery; however, its long‐term oncological relevance has not been prospectively validated in Japan, where upfront surgery has long been widely used. This study ass...