Huzhou Central Hospital

Pola-R-CHP in previously untreated DLBCL with international prognostic index score 0–1: a multicenter real-world retrospective study in China

Abstract Purpose Approximately 30% of newly diagnosed diffuse large B-cell lymphoma (DLBCL) cases are categorized as low-risk by the international prognostic index (IPI). Polatuzumab vedotin, rituximab, cyclophosphamide, doxorubicin, and prednisone (Pola-R-CHP) has demonstrated e...

High-voltage pulsed radiofrequency combined with tolerable thermocoagulation for the treatment of postherpetic neuralgia: study protocol for a randomized controlled trial

Postherpetic neuralgia (PHN) is a common and debilitating complication of herpes zoster that significantly affects patients’ quality of life, particularly among elderly and immunocompromised individuals. Although pharmacological therapies are widely used, they often provide limit...

Bacterial communication in the gut: interbacterial and bacteria-host crosstalk

The human gut harbors a complex ecosystem in which bacteria engage in interbacterial and bacteria-host communication through diverse molecular languages to orchestrate collective behaviors and host interactions. This review explores the principal mechanisms and mediators of bacte...

The pregnancy vaginal microbiota exhibits alterations in association with gravidity, parity, and miscarriage history: a cohort study

Vaginal microbiota plays a critical role in reproductive health, yet the impact of woman’s obstetric history including gravidity, parity and miscarriage history, remains inadequately characterized. We conducted a cohort study to identify microbial biomarkers linked to these facto...

Effect of transcutaneous auricular vagus nerve stimulation on postoperative gastrointestinal dysfunction in patients with gynecological abdominal or pelvic tumors: a study protocol for a prospective, single-center, randomized, controlled clinical trial

BACKGROUND: Postoperative gastrointestinal dysfunction (POGD) commonly presents with nausea, vomiting, abdominal distension, delayed flatus or stool, and prolonged intolerance to oral intake. It can cause postoperative pain, delayed gastrointestinal motility, or intestinal obstru...

Deep learning radiomics based on preoperative multiparametric MRI in predicting breast cancer recurrence risk

Breast cancer treatments are often tailored to recurrence risk to improve outcomes, but reliable risk stratification methods are lacking. To predict preoperative breast cancer recurrence risk through a tridimensional synergy model integrating breast MRI, radiomics, and deep learn...

Association between the HbA1c/HDL-C ratio and cardiovascular disease risk: a cross-cohort analysis in NHANES and CHARLS

Cardiovascular disease (CVD) remains a leading cause of mortality worldwide, with glucose and lipid metabolic disturbances closely involved. We therefore assessed how the glycated hemoglobin (HbA1c)/ high-density lipoprotein cholesterol (HDL-C) ratio (HHC) relates to composite CV...

Cholesterol metabolism-immune gene prognostic model in colorectal cancer

To investigate the association between serum cholesterol and the occurrence of colorectal cancer (CRC), and to construct a prognostic model for CRC based on cholesterol metabolism-related genes (CMG), clarifying the model's relationship with immune infiltration. Serum cholesterol...

A study on the utility of velocity vector imaging for assessment of radial artery elastic function in patients with end-stage renal disease

Objective: This study aims to assess changes in radial artery elastic function among patients with end-stage renal disease (ESRD) using velocity vector imaging (VVI). Methods: A retrospective analysis was conducted on 68 pre-hemodialysis ESRD patients and 30 healthy individuals a...