Hunan Provincial People's Hospital

Nomogram model based on dual-energy CT quantitative parameters and radiomics for preoperative prediction of microvascular invasion in hepatocellular carcinoma

Abstract Objective To explore the potential value of a nomogram model based on dual-energy CT (DECT) quantitative parameters and radiomics for preoperative prediction of microvascular invasion (MVI) in hepatocellular carcinoma. Methods A retrospective analysis was conducted on 14...

Neuroprotection in the early window: a randomized controlled trial of butylphthalide initiation within 3 hours in acute ischemic stroke

Neuroprotective agents have shown promise in preclinical studies but failed to demonstrate efficacy in clinical trials, potentially due to delayed treatment initiation. The optimal therapeutic window for neuroprotection in acute ischemic stroke (AIS) remains undefined. We aimed t...

Dual-organelle–coordinated sonodynamic nanoplatform amplifies immunogenic cell death to drive robust antitumor immunity in cold tumors

Immune-excluded “cold” tumors are characterized by dense stromal barriers, limited cytotoxic T-cell infiltration, and insufficient immunogenic cell death (ICD), which collectively restrict the efficacy of immunotherapy. Pancreatic ductal adenocarcinoma (PDAC) and triple-negative...

Development and validation of a two-gene urine DNA methylation assay for noninvasive prostate cancer detection: a prospective multicenter study

Prostate-specific antigen (PSA) screening lacks specificity, particularly within the 4-10 ng/mL diagnostic gray zone, leading to unnecessary prostate biopsies and overtreatment. Here, we developed and validated a streamlined urine DNA methylation assay for non-invasive prostate c...

OTOF Promotes Clear Cell Renal Cell Carcinoma Progression and Angiogenesis Through AKT-Dependent HIF/VEGFA Signaling

Background: Clear cell renal cell carcinoma (ccRCC) is characterized by marked molecular heterogeneity, aggressive clinical behavior, and prominent angiogenesis, highlighting the need to better understand the functional regulators underlying tumor progression and vascular remodel...

Analytical Method for Surrounding ROCK Pressure of Shallow-Buried Double-Arch Tunnels Under Variable-Slope Ground Surfaces

Based on limit-equilibrium theory, a calculation method for the surrounding rock pressure of shallow-buried variable-slope arch tunnels is proposed. A calculation model for surrounding rock pressure of variable-slope surfaces is established according to the structure and stress c...