Hunan Provincial People's Hospital

Intensive Care Unit Patients' Perspectives and Experiences in Using Virtual Reality Technology: A Qualitative Meta‐Synthesis

BACKGROUND: As Intensive Care Unit (ICU) survival improves, attention has shifted towards patients' psychological well-being and recovery. Although Virtual Reality (VR) is increasingly used in critical care, patients' experiences of VR interventions have not been comprehensively...

From Liberal to Punitive: A Qualitative Meta-Synthesis of Multilevel Health Needs Among MSM Engaged in Chemsex

Chemsex among men who have sex with men (MSM) is a complex health issue shaped by individual, interpersonal, community, and structural factors. This systematic review aimed to synthesize the lived experiences and healthcare needs of MSM engaging in chemsex across diverse sociocul...

AICD-associated MMP1 in ovarian cancer: Prognostic, spatial, and functional evidence

Background Ammonia-induced cell death (AICD) is a recently described form of regulated cell death, but the clinical relevance of AICD-associated genes in ovarian cancer remains unclear. Methods Transcriptomic and clinical data from TCGA-OV and four GEO cohorts were used to evalua...

Arthroscopic 'Luggage Tag' suture repair technique for acetabular labral injuries

This study aimed to evaluate the clinical efficacy of hip arthroscopic luggage-tag suture repair for the treatment of acetabular labral tears. This single-center retrospective study was approved by the institutional ethics committee and enrolled 33 patients with acetabular labral...

Potential therapeutic effects of Lactobacillus on Pancreatic ductal adenocarcinoma through its metabolite Harmaline

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and lethal form of cancer. Recent research has uncovered the role of the gut microbiota in influencing PDAC progression and treatment outcomes. Dysbiosis of gut microbiota in PDAC patients has been shown to negatively...

Synergistic catalytic therapy of severe acute pancreatitis using gold-doped prussian blue nanozymes via targeting ROS-NLRP3 inflammatory cascade

Severe acute pancreatitis (SAP) is characterized by a complex and poorly understood pathogenesis, with a lack of specific therapeutic agents. Herein, we develop morphology-engineered gold-doped Prussian blue nanozymes (AuPB), designed as reactive oxygen species (ROS) scavengers f...

Potential of plasma metagenomic next-generation sequencing to guide antibiotic therapy in acute necrotizing pancreatitis with early fever: a prospective multicenter cohort study

Indiscriminate antibiotic use remains common in febrile patients with acute necrotizing pancreatitis (ANP), particularly during the early phase. Metagenomic next‑generation sequencing (mNGS) has shown diagnostic utility for infected pancreatic necrosis (IPN) and may offer a means...

Reliability and Validity of the Chinese Version of the Parental Acceptance Questionnaire (6‐PAQ) Among Parents of Children With or Without Hearing Loss

ABSTRACT Background The parental acceptance questionnaire (6‐PAQ) is a user‐friendly and contextually sensitive scale of psychological flexibility. Objective This research aimed to translate the original English version of the 6‐PAQ into Chinese and to test its psychometric prope...

Nomogram model based on dual-energy CT quantitative parameters and radiomics for preoperative prediction of microvascular invasion in hepatocellular carcinoma

Abstract Objective To explore the potential value of a nomogram model based on dual-energy CT (DECT) quantitative parameters and radiomics for preoperative prediction of microvascular invasion (MVI) in hepatocellular carcinoma. Methods A retrospective analysis was conducted on 14...

Neuroprotection in the early window: a randomized controlled trial of butylphthalide initiation within 3 hours in acute ischemic stroke

Neuroprotective agents have shown promise in preclinical studies but failed to demonstrate efficacy in clinical trials, potentially due to delayed treatment initiation. The optimal therapeutic window for neuroprotection in acute ischemic stroke (AIS) remains undefined. We aimed t...

Dual-organelle–coordinated sonodynamic nanoplatform amplifies immunogenic cell death to drive robust antitumor immunity in cold tumors

Immune-excluded “cold” tumors are characterized by dense stromal barriers, limited cytotoxic T-cell infiltration, and insufficient immunogenic cell death (ICD), which collectively restrict the efficacy of immunotherapy. Pancreatic ductal adenocarcinoma (PDAC) and triple-negative...

Development and validation of a two-gene urine DNA methylation assay for noninvasive prostate cancer detection: a prospective multicenter study

Prostate-specific antigen (PSA) screening lacks specificity, particularly within the 4-10 ng/mL diagnostic gray zone, leading to unnecessary prostate biopsies and overtreatment. Here, we developed and validated a streamlined urine DNA methylation assay for non-invasive prostate c...

OTOF Promotes Clear Cell Renal Cell Carcinoma Progression and Angiogenesis Through AKT-Dependent HIF/VEGFA Signaling

Background: Clear cell renal cell carcinoma (ccRCC) is characterized by marked molecular heterogeneity, aggressive clinical behavior, and prominent angiogenesis, highlighting the need to better understand the functional regulators underlying tumor progression and vascular remodel...

Analytical Method for Surrounding ROCK Pressure of Shallow-Buried Double-Arch Tunnels Under Variable-Slope Ground Surfaces

Based on limit-equilibrium theory, a calculation method for the surrounding rock pressure of shallow-buried variable-slope arch tunnels is proposed. A calculation model for surrounding rock pressure of variable-slope surfaces is established according to the structure and stress c...