Hunan Provincial Maternal and Child Health Hospital

Cisplatin combined with high-intensity focused ultrasound inhibits endometrial cancer progression by inducing pyroptosis

Background Cisplatin-based chemotherapy is limited by toxicity and resistance.High-intensity focused ultrasound (HIFU) is a noninvasive ablation technique with potential to enhance chemotherapy efficacy.Objective To investigate the anti-tumor effects and mechanisms of cisplatin c...

Targeting the m6A reader YTHDF1 for overcoming cancer therapeutic resistance and enhancing tumor immunotherapy

N6-methyladenosine (m⁶A) is a major post-transcriptional RNA modification that regulates RNA stability, translation, degradation, and immune-related gene expression. As a key m⁶A reader, YTHDF1 mainly promotes the translation of m⁶A-modified transcripts and has emerged as an impo...

Label-Free Electrochemical Aptasensor Based Upon Thionine-Modified Molybdenum(IV) Sulfide Nanosheets for the Sensitive Determination of Prostate-Specific Antigen (PSA)

Prostate-specific antigen (PSA) is an important biomarker for the early diagnosis and monitoring of prostate cancer. To address the limitations of conventional diagnostic approaches and facilitate PSA analysis, a label-free electrochemical aptasensor based on thionine-modified mo...

Neural-specific UBAP2L deficiency causes developmental delay and cortical abnormalities in mice

Rare UBAP2L variants have been linked to neurodevelopmental disorders (NDDs), such as autism spectrum disorder (ASD), but the role of UBAP2L in brain development remains unclear. Here, we generated neural-specific conditional knockout mice for Ubap2l using Nestin-Cre system, incl...

Maternal di(2-ethylhexyl) phthalate (DEHP) exposure alters offspring gut microbiota and the colonic transcriptome in a sex-specific manner

Maternal exposure to the plasticizer DEHP during gestation and lactation programs lasting sex-specific alterations in offspring intestinal health. This study investigated the transgenerational effects of perinatal DEHP exposure on offspring intestinal health using a C57BL/6 mouse...

Risk factors for gestational hypertension and preeclampsia: a multivariate logistic regression analysis in a less-developed province in south-central China, 2012–2022

To explore risk factors for gestational hypertension and preeclampsia. Data were obtained from the Maternal Near-Miss Surveillance System in Hunan Province, China, 2012–2022. Multivariate logistic regression analysis (method: Enter, α = 0.05) and odds ratios (ORs) were used to id...