Hunan Children's Hospital

Multi-omics Mendelian randomisation reveals distinct molecular drivers of pathological myopia complications vs simple myopia

Background: Pathological myopia complications are leading causes of irreversible blindness, yet the molecular mechanisms distinguishing them from simple myopia remain poorly understood. We aimed to compare the molecular profiles associated with pathological myopia complications a...

From bowing to fracture

Aims Congenital anterolateral bowing of the tibia represents the prefracture stage of congenital pseudarthrosis of the tibia. However, specific radiological factors which are predictive of fracture remain poorly defined. The aim of this study, therefore, was to investigate whethe...

Prognostic Associations of BMI and Metabolic Syndrome With Outcomes After Anti‐ PD ‐1 Therapy in Recurrent or Metastatic Nasopharyngeal Carcinoma

ABSTRACT To evaluate the associations of body mass index (BMI) and metabolic syndrome (MetS) with outcomes in patients with recurrent or metastatic nasopharyngeal carcinoma (R/M‐NPC) receiving anti‐PD‐1 therapy, and to develop a prognostic model for overall survival (OS). This mu...

Outcomes of the modified Woodward procedure with and without concomitant clavicular osteotomy and intraoperative neurophysiological monitoring for Sprengel deformity: a retrospective cohort study with a minimum 2-year follow-up

Surgical treatment of Sprengel deformity aims to improve shoulder symmetry and active shoulder motion while avoiding neurovascular injury. Whether clavicular osteotomy should be added to the modified Woodward procedure remains controversial, particularly because intraoperative ne...

A large-scale multi-center analysis reveals that HNRNPA2B1 variants increase neuroblastoma risk in Chinese children

Neuroblastoma has significant clinical heterogeneity, more precise genetic biomarkers are needed for early risk stratification. Although m 6 A modification has been reported to affect tumor development, the epidemiological impact of HNRNPA2B1 polymorphisms on neuroblastoma suscep...

Clcn6 mRNA and ClC-6 protein expression in mouse central nervous system

To investigate the expression patterns of Clcn6 mRNA and ClC-6 protein in postnatal mouse of distinct region of central nervous system (CNS) and developmental stages. Distinct CNS regions, including cerebral cortex, hippocampus, cerebellum, brainstem, olfactory bulb, hypothalamus...

Subcutaneous Belimumab Demonstrates Consistent Steady-State Pharmacokinetics and is Well Tolerated in Paediatric Patients with SLE in China: An Open-Label Study

This study assessed pharmacokinetics and safety of subcutaneous (SC) belimumab in Chinese paediatric patients with systemic lupus erythematosus (cSLE) who previously received intravenous (IV) belimumab; only the IV form is approved for cSLE in China. This single-arm, open-label,...