Institution
HUN-REN Research Centre for Natural Sciences
Recent research
- BiologyOpen access
Ligand-based pharmacophore modeling for the discovery of NaV1.7 inhibitors
Abstract Voltage-gated sodium channel Na V 1.7 is a key mediator of electrical excitability and signal transmission in peripheral nociceptors and has emerged as a highly attractive therapeutic target for the development of novel analgesic agents. However, the development of selec...
- Materials & Energy
Abstract Morpholine-functionalized 8-hydroxyquinoline (HQ) derivatives with reduced Schiff base linkers, Morph-Et-HQ and Morph-Pr-HQ, were synthesized and comprehensively characterized to investigate the influence of linker length on donor-set preference, metal binding, and the b...
- BiologyOpen access
No gender differences in predictive processing
Abstract Statistical learning, defined as the implicit extraction of environmental regularities, is considered a fundamental cognitive mechanism that supports predictive processing across individuals, domains, and species. However, whether it is modulated by gender remains unclea...
- Health & MedicineOpen access
Abstract Background Despite guideline-recommended treatment, approximately 30% of rheumatoid arthritis (RA) patients remain symptomatic and are classified as difficult-to-treat (D2T), representing an unmet clinical need. D2T RA is a heterogeneous state potentially involving diffe...