HUN-REN Institute of Experimental Medicine

Transcriptome profiling of human hypothalamic agouti-related protein and proopiomelanocortin neurons regulating energy homeostasis

Abstract We present and validate a pioneering ‘IHC/LCM-Seq’ method for transcriptome profiling of spatially defined neuronal cell types detected with immunohistochemistry in sections of formaldehyde-fixed human brains. Application of IHC/LCM-Seq to male human hypothalami enables...

Sensory stimulation triggers different spike responses in serotonin and dopamine neurons in the dorsal midbrain tegmentum

Abstract The dorsal midbrain tegmentum, including the dorsal raphe nucleus (DRN) and the ventrolateral periaqueductal gray (vlPAG), contains diverse neuronal populations. Within this region, serotonin (5-HT) and dopamine (DA) neurons are the principal monoaminergic cell types and...

Ligand-based pharmacophore modeling for the discovery of NaV1.7 inhibitors

Abstract Voltage-gated sodium channel Na V 1.7 is a key mediator of electrical excitability and signal transmission in peripheral nociceptors and has emerged as a highly attractive therapeutic target for the development of novel analgesic agents. However, the development of selec...