Human Technopole

Elevated prenatal IL-6 levels disrupt early patterns of hippocampal electrical activity and chloride homeostasis by targeting GABAergic signaling at perinatal stage

Abstract Early patterns of neuronal electrical activity are fundamental for driving critical developmental processes, including neuronal maturation and synapse formation. While genetic programs are key in orchestrating these events, the influence of environmental stressors remain...

Time-lapse RESOLFT nanoscopy empowered by deep learning

Abstract Capturing the dynamic interplay of proteins and organelles within cells requires microscopy methods with high spatial and temporal resolution. Reversible Saturable OpticaL Fluorescent Transition (RESOLFT) demonstrated great potential for live cell nanoscopy by using patt...

Automated SSIM regression for detection and quantification of motion artefacts in brain MR images

Abstract Motion artefacts in magnetic resonance brain images can have a strong impact on diagnostic confidence. The assessment of MR image quality is fundamental before proceeding with the clinical diagnosis. Motion artefacts can alter the delineation of structures such as the br...

Integrated Multi‐Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC

ABSTRACT Ductal carcinoma in situ (DCIS) is a non‐invasive precursor of invasive ductal carcinoma (IDC), yet the biological mechanisms underlying the transition from DCIS to IDC remain incompletely understood. Here, we integrate spatial transcriptomics, single‐cell RNA sequencing...

Sensing‐Integrated Patient‐Derived Tumorspheres Predict Chemotherapeutic Efficacy via Local Extracellular pH Dynamics

ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest malignancies, due to late diagnosis, poor therapeutic response, and high inter‐ and intra‐patient heterogeneity. Metabolic alterations, particularly extracellular acidification, critically impair drug respons...