Hull York Medical School

Bibliometric mapping of the 100 most-cited publications on optic nerve and optic pathway glioma

Background: Optic pathway gliomas (OPGs), including optic nerve gliomas, are uncommon tumors of the anterior visual pathway that arise mainly in young children, often with neurofibromatosis type 1 (NF1). The literature is now substantial, but its structure is undescribed. We mapp...

ACTIVATE: A protocol for a randomised controlled evaluation of Thumos: A cognitive-behavioural intervention for medical students

Background Medical students experience high rates of burnout and mental health distress, with approximately half reporting burnout, one-third experiencing depression, and one-tenth having suicidal thoughts. These issues are exacerbated during clinical placements and contribute to...

TH1177, Clemastine, and Benzhydryl Derivatives Act as Novel Extracellular Blockers of ORAI Channels

ORAI channels are store-operated Ca2+ channels, which play important roles in physiology and pathophysiology. ORAI channel modulators are useful for developing pharmacological interventions. Here, we aimed to investigate the benzhydryl-derived analogues as novel ORAI channel bloc...

Addressing evidence gaps in haemodialysis care: a critical review of clinical trials, technological innovations, and implementation priorities

Kidney failure treated with maintenance haemodialysis (HD) carries high risks of premature mortality, hospitalisation and impaired quality of life, yet important evidence gaps persist across routine HD care. The Dialysis Research Innovation Network, part of the UK Kidney Research...

Quantifying care provided to children and young people with cancer who die: Estimating the costs and key determining factors of NHS secondary care in England

Background Little is known about hospital use, costs, and factors associated with higher costs in end-of-life care for children and young people with cancer who die. Methods This is a retrospective death-outcome defined cohort study. It included 4,247 children and young people ag...

Involving People With Dementia in Research: Contributions, Barriers and Evaluation From a Meta‐Synthesis and Qualitative Interview Study

BACKGROUND: Patient and Public Involvement and Engagement (PPIE) can enhance the relevance, acceptability and quality of research; however, its meaningful implementation in dementia research remains insufficiently understood. AIM: (1) To identify methodological procedures for inv...

“We don’t get asked”: including people with workforce experience as public contributors in a workforce-related study about homecare work towards the end-of-life

Abstract Background Homecare workers are an undervalued but essential part of the health and care workforce in England, providing vital end-of-life care without adequate training or support. Through the SUPPORTED study we explored the experiences, training and support needs of ho...

Retinotopic remapping of the visual system in deaf adults

Abstract Deaf individuals rely on visual rather than auditory cues to detect events in the periphery, putting a greater demand on neural resources for vision. Comparing visual maps in the brains of early deaf and hearing adults, we found a redistribution of neural resources in th...

Comparing the GP-CORE and WEMWBS Scores as Predictors of Future Mental Health Service Utilisation and Help-Seeking Behaviour Among UK Students in Higher Education

Background The General Population Clinical Outcomes in Routine Evaluation (GP-CORE) and the Warwick-Edinburgh Mental Well-being Scale (WEMWBS) are two instruments often used to measure psychological distress or well-being in student samples. This study aimed to directly compare t...

The Genetic Architecture of Chronic Cough: From Sensory Hypersensitivity to Treatable Trait

Chronic cough is a prevalent global clinical disorder with substantial quality-of-life impairment, and refractory cases remain a major unmet medical need. Cough hypersensitivity syndrome is the core pathological mechanism of chronic cough, and growing genetic evidence has confirm...

A conserved grain-associated immunosuppressive niche in Sudanese patients with mycetoma

Abstract Mycetoma is a neglected tropical disease caused by various bacterial and fungal pathogens that has a significant health impact across a broad geographically defined “mycetoma belt” spanning South America, Africa and Asia. Histologically, mycetoma is characterised by inva...

‘Talk CKD Options’: improving how clinicians communicate treatment options in advanced kidney disease using a conversation analysis-based training intervention

Abstract Background Most older people with kidney failure and multiple co-morbidities must decide between dialysis or conservative kidney management. Dialysis is often presented as the default, despite providing uncertain survival benefits in this population. The Optimising Staff...

Benefits and challenges of a Patient & Public Involvement (PPI) peer researcher

Involving a patient and public involvement (PPI) peer researcher with lived experience in clinical research is a relatively new concept and to our knowledge, has not been described in adult cardiac surgery. The integration of a PPI peer researcher with a lived experience of a sur...

Aflibercept 8 mg in neovascular age-related macular degeneration and diabetic macular oedema: Translating clinical trials into clinical practice

Abstract Provide expert-informed guidance on the integration of aflibercept 8 mg into routine clinical care for patients with neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DMO), based on clinical trial and real-world evidence. Sixteen retina spe...

Metabolic Stress Testing Reveals Persistent Lipid‐Handling Dysfunction in Women With Polycystic Ovary Syndrome Despite Exercise Training

ABSTRACT Aim Polycystic ovary syndrome (PCOS) is associated with insulin resistance and metabolic dysfunction, yet baseline metabolomic studies show inconsistent findings. We investigated whether metabolic abnormalities in PCOS emerge under physiological stress and how these resp...