Huizhou Central People's Hospital

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

Immune–metabolic heterogeneity and prognostic associations in breast cancer: development of an eight-gene risk model and preliminary functional characterization of NAT2

Abstract Breast cancer is highly heterogeneous, and immune–metabolic interactions within the tumor microenvironment may contribute to differences in clinical outcome. In this study, transcriptomic, clinical, and somatic mutation data from TCGA-BRCA were analyzed, and the prognost...

An exploratory study of safety and efficacy of camrelizumab plus induction chemotherapy followed by concurrent chemoradiotherapy for locally advanced nasopharyngeal carcinoma

This study aims to prospectively evaluate the safety and efficacy of camrelizumab plus induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) in locally advanced nasopharyngeal carcinoma (LA-NPC). This prospective study (ChiCTR2500102158) enrolled patients with hi...

A study of medical students’ perception of the risk of future job displacement and adaptive behaviors in the context of artificial intelligence

Abstract Against the backdrop of rapid advances in artificial intelligence (AI) technology, an increasing number of jobs are facing significant challenges, particularly in the healthcare sector. The development of AI not only puts forward new career requirements for healthcare pr...

A novel HSD3B2 variant of uncertain significance (c.64_66del, p.Leu22del) in a female infant with 3β-hydroxysteroid dehydrogenase deficiency presenting with completely normal external genitalia: a case report

Abstract Background 3β-Hydroxysteroid dehydrogenase (3β-HSD) deficiency is a rare form of congenital adrenal hyperplasia (CAH), typically presenting with salt-wasting and, in females, ambiguous genitalia, or undervirilization in males. Case presentation We report the case of a 10...

Predicting left-ventricular recovery and characterizing Cardiorenal risk after Transcatheter aortic valve replacement: A routine-data phenotyping and prediction-model study

Background Ejection fraction (LVEF) underpins risk stratification before transcatheter aortic valve replacement (TAVR), yet it does not indicate whether an impaired ventricle will recover once the stenosis is relieved, or what drives death in high-risk patients. We asked whether...

LRCH4 drives tumor cell proliferation by regulating the GSK3B/MEK/ERK axis in colorectal cancer

Abstract Leucine-rich repeat-containing protein 4 (LRCH4), a member of the LRCH family, has emerged as a potential prognostic biomarker in several cancers, including colorectal cancer (CRC). While other proteins in this family have been implicated in tumorigenesis, the specific r...

Machine learning identifies ac4C-related prognostic signature and TUBA1C as therapeutic target in COAD

To explore the role of N4-acetylcytidine (ac4C)-related genes (acRGs) in colon adenocarcinoma (COAD) and identify reliable prognostic biomarkers and potential therapeutic targets. Multi-source transcriptomic datasets (TCGA-COAD, GSE39582, GSE17536) and single-cell RNA-seq data we...

Identification of RAB36 and NINL as potential diagnostic biomarkers for gestational diabetes mellitus and polycystic ovary syndrome

Gestational diabetes mellitus (GDM) and polycystic ovary syndrome (PCOS) are common endocrine and metabolic disorders in women, with PCOS increasing the risk of GDM. However, shared molecular markers that could support early diagnosis and the mechanisms underlying them remain ins...

Uncertainty-inspired open-set model for identifying infantile fundus abnormalities

Accurate and safe identification of infantile fundus abnormalities is critical for large-scale screening, yet remains challenging because of heterogeneous disease presentations and overconfident predictions by conventional artificial intelligence (AI) models. In this study, we ai...

Individualized hybrid electroconvulsive therapy (i-HECT) shows rapid anti-depressant effect in young patients with depression

Abstract Background For young patients with depression, electroconvulsive therapy (ECT) is highly effective but causes acute cognitive side effects. We designed a new individualized hybrid electroconvulsive therapy (i-HECT) combines ECT with low-charge electrotherapy (LCE) and in...