Hubei University of Science and Technology

LMOD2 attenuates Ang II-induced cardiomyocyte hypertrophy by activating the Nrf2-mediated antioxidant pathway

Pathological cardiac hypertrophy constitutes a common pathway in heart failure progression. Although previous studies have identified LMOD2 as a protective factor against dilated cardiomyopathy, its functional role and mechanistic involvement in pathological hypertrophy remain el...

Recombinant humoral immune proteins differentially modulated Cry1Ac susceptibility in Plutella xylostella

The insect immune system is closely associated with Bt resistance. Our previous studies have shown that silencing humoral immune genes (PxPGRP2, PxIMD, PxSPN1 and PxPPO1) in Plutella xylostella significantly affected larval susceptibility to Cry1Ac and also impacts fecundity. How...

Recombinant humoral immune proteins differentially modulated Cry1Ac susceptibility in Plutella xylostella

The insect immune system is closely associated with Bt resistance. Our previous studies have shown that silencing humoral immune genes (PxPGRP2, PxIMD, PxSPN1 and PxPPO1) in Plutella xylostella significantly affected larval susceptibility to Cry1Ac and also impacts fecundity. How...

The mechanism of vascular injury caused by polystyrene microplastics: Involving ferroptosis and metabolomics

Polystyrene microplastics (PS-MPs) are environmental pollutants linked to cardiovascular diseases. This study investigated PS-MP-induced vascular toxicity mechanisms in mice. Mice were divided into saline control, low/medium/high PS-MP exposure (0.1, 1, and 10 mg/kg/d), and PS-MP...

AIS-Based Forecasting of STEAM-Estimated Ship CO2 Emissions for Sustainable Maritime Transportation Using a Spatio-Temporal Graph Transformer

Accurate short-horizon forecasting of ship CO2 emissions is important for maritime carbon monitoring, operational assessment, and the transition toward sustainable maritime transportation. However, reliable forecasting remains challenging because ship emissions are affected by te...

An enhanced model for accurate fish keypoint detection and tracking in intensive aquaculture

Monitoring fish growth is critical for intensive aquaculture, yet traditional manual weighing methods are labor-intensive and inefficient. This study proposes FishPose-tracking, an enhanced deep learning model that automates keypoint detection and tracking of fish, improving the...

Deposition and Aero-Thermal Synergetic Design of Internal Swirl Cooling for a Turbine Blade Leading Edge: GAN-Based Optimization

Abstract The leading edge of turbine blades is subjected to extreme thermal loads, exaggerated by continuously increasing turbine inlet temperatures. This challenge has motivated the development of increasingly sophisticated internal cooling architectures. However, such intricate...

In-Situ Growth of Bimetallic ZnCo-ZIF-67 on Carbon Fibers as High-Efficiency Catalyst for Enhancing Thermal Decomposition of Ammonium Perchlorate

Due to its abundant active sites, the bimetallic zeolite imidazole framework ZnCo-ZIF-67 exhibits excellent catalytic performance on the key oxidant ammonium perchlorate in composite solid propellants. In addition, carbon fiber has been proven to promote the combustion of propell...

DARS2 Promotes Tumorigenesis and Metastasis by Activating PI3K / Akt / GSK ‐3β/β‐Catenin Signaling Pathway in Breast Cancer

ABSTRACT Aspartyl‐tRNA synthetase 2 (DARS2), the mitochondrial enzyme responsible for aminoacylation of aspartyl‐tRNA, is traditionally known for its effect on protein synthesis. Recently, DARS2 is reported to be implicated in tumorigenesis. However, its specific effect on breast...

Ubiquitination in cancer: mechanisms, signaling networks and potential therapeutic opportunities

Protein ubiquitination is among the most important posttranslational modifications in eukaryotes. It precisely regulates protein stability and cellular signaling through the ubiquitin‒proteasome system (UPS). A dynamic equilibrium network formed by the E1-E2-E3 enzymatic cascade...

A tributyrin-monolaurin complex protects piglets against PEDV infection via viral inhibition, lipid metabolism restoration, and microbiota modulation

Porcine epidemic diarrhea virus (PEDV) is a major pathogen causing severe diarrhea and intestinal damage in piglets. Monolaurin (GML) and tributyrin (TB) are well-documented functional lipids with intestinal health benefits, but their combined efficacy against PEDV infection rema...