Hubei University of Chinese Medicine

Complete biosynthesis of the clinical agent escin Ia

Abstract Escin Ia is a barrigenol-type triterpenoid specific to Aesculus seeds and is widely utilized in clinical practice for the treatment of cerebral edema, swelling, and venous insufficiency. Here, we fully elucidated its biosynthetic pathway by identifying ten previously unc...

Structural insights into a substrate translocation pathway revealed by the RND efflux pump complex MexJK from Pseudomonas aeruginosa

Resistance–nodulation–cell division (RND) efflux pumps are the major cause of multidrug resistance in Pseudomonas aeruginosa . The inner membrane protein MexK from P. aeruginosa is a narrow-spectrum RND transporter. It assembles with membrane fusion protein MexJ and outer membran...

Anti-inflammatory mechanisms underlying sympathetic nervous system–mediated acupuncture analgesia

Sympathetic nerves play an important role in the generation and maintenance of pain, and many studies have shown that inflammatory factors play an important role in this process. During tissue inflammation or injury, the interaction between sympathetic nerves and the sensory nerv...

Sex-specific effects of methylprednisolone on outcomes after endovascular treatment for acute ischemic stroke due to large vessel occlusion: A secondary analysis of the MARVEL trial

Background Sex-based differences in treatment response to neuroprotective strategies during endovascular treatment (EVT) for acute ischemic stroke remain poorly understood. Objectives This study aimed to evaluate sex-specific effects of methylprednisolone on outcomes after EVT fo...