Institution
Huazhong University of Science and Technology Hospital
Recent research
- Biology
Abstract Camptothecin (CPT), a classical topoisomerase I (TOP I) inhibitor, shows potent antitumor activity but is limited by toxicity and lactone instability. Herein, structural optimization of the CPT scaffold was conducted via A-ring fluorination and C-7 and C-17 modifications...
- Biology
LAMP: Large-Area Molecular Mapping Platform
Abstract By providing unique chemical specificity and quantitative metabolic imaging, label-free stimulated Raman scattering (SRS) and coherent anti-Stokes Raman scattering (CARS) microscopy is now emerging as the next-generation clinical decision maker by providing molecular con...
- Engineering & Technology
Abstract The advancement of rechargeable batteries has long been dominated by two principal paradigms: single-ion and dual-ion mechanisms. The single-ion mechanism, operating via the shuttling of monovalent cations, offers high energy density yet suffers from inherent kinetic lim...
- Materials & Energy
Abstract Utilizing agro-industrial wastes/byproducts as feedstocks for functional polymers offers a promising approach to alleviating urgent resource shortages. Herein, elemental sulfur (an oil-refining byproduct) and renewable diisocyanide/diamine (agrowate derivatives) were emp...
- Climate & Environment
Elevation Amplifies Carrier-Type Differences in Nitrogen Cycling and N 2 O Dynamics in Lake Biofilms
Abstract Lake biofilms are microbial habitats for nitrogen transformation, but how carrier type and elevation influence N2O dynamics remains unclear. We examined abiotic- and biotic-carrier biofilms from 12 lakes spanning 4–4272 m using anoxic incubations, 15N tracing, selective...
- Health & Medicine
Abstract Poly(ADP-ribose) polymerase 1 (PARP-1) inhibitors yield robust clinical benefits yet only work for homologous recombination deficiency (HRD) patients. To expand their utility and resolve clinical drawbacks, we synthesized dual PARP-1/casein kinase II alpha (CK2α) inhibit...
- Materials & Energy
In-Sensor Visible and Mid-Infrared Dual-Band Perception and Computing
Abstract Machine vision in complex environments requires hardware that can integrate multispectral sensing with real-time front-end information processing. Visible light (VIS) and mid-infrared (MIR) signals provide complementary scene information, yet existing photodetectors cann...
- Materials & Energy
Abstract Valorizing sustainable biomass resources into high-value functional electrocatalytic materials provides a promising approach to address energy and environmental issues, especially for urea electrolysis. However, urea electrolysis is predominantly bottlenecked by sluggish...
- Materials & Energy
Abstract The evolution of magnetic properties in molybdenum chloride systems caused by structural motif changes was investigated by magnetic property measurements and DFT calculations. In ξ-MoCl5, characterized by the presence of molybdenum dimers, the formation of ferromagnetic...
- Engineering & Technology
On Multi-Source Sludge Smoldering Process
Abstract Smoldering, as an emerging technology, exhibits significant potential for the efficient disposal of organic solid waste with high moisture content; however, theoretical models targeting multi-source blended fuels remain scarce. This work systematically investigates the s...
- AI & ComputingOpen access
Assessing China’s COVID-19 control measures: a quantitative analysis based on a SIRD model
Abstract This paper established a Susceptible-Infected-Recovered-Dead (SIRD) model to fit and predict the COVID-19 epidemic in China. On the premise of passing the Markov Chain Monte Carlo (MCMC) robustness check, we counterfactually assessed the effectiveness of partial unlockin...
- Health & Medicine
Summary Lower levels of sitting time were associated with a lower risk of severe asthma exacerbations in adults. High levels of physical activity eliminated the detrimental association of sitting time with severe asthma exacerbations in adults.
- Engineering & Technology
Abstract Fungal infections represent a significant global health threat, exacerbated by the scarcity of new therapeutic options, increasing drug resistance, and host toxicity. Sonodynamic therapy (SDT) offers a promising approach to overcoming antimicrobial resistance by enabling...
- Engineering & Technology
Abstract Lithium (Li) metal batteries represent a transformative candidate for high-end energy storage due to their ultra-high energy density. However, commercial polyolefin separators suffer from poor thermal stability and insufficient electrolyte wettability, resulting in high...
- Engineering & Technology
Aggregation-Induced Emission: Illuminating the Path from Photothermal Ablation to Systemic Immunity
Abstract Cancer photothermal immunotherapy has attracted great attention in cancer treatment for its ability to trigger systemic antitumor immune responses and reverse tumor immune tolerance, offering prospects for clinical application. However, conventional photothermal agents s...
- BiologyOpen access
Abstract Despite undergoing exposure therapy, individuals with post-traumatic stress disorder (PTSD) frequently experience relapses when confronted with trauma reminders. This study examined the impact of extinction-restraint intervention (Ext-Res) in a PTSD-related fear relapse...
- Materials & Energy
Abstract Metal oxides are commonly used as supports for catalysts for CO2 hydrogenation. However, systematic studies on the influence of different metal oxide supports on the catalytic performance of catalysts for light olefin production remain limited. Therefore, a series of cob...
- Engineering & Technology
Abstract Photocatalytic valorization of lignin into value-added aromatic chemicals constitutes a sustainable strategy for utilizing renewable biomass resources. However, the efficiency of this process is hampered by the requirement of harsh conditions and the inherent complexity...
- Physics & Space
Hybrid Ultrahigh-QualityEtchless Microcavity forApplications with Low-Dimensional Materials
Abstract Two-dimensional (2D) materials possess exceptional optical properties, holding great potential for the development of advanced linear and nonlinear optoelectronic devices. However, their efficient integration into photonic circuits remains challenging due to the trade-of...
- Society & Economics
How Do Households Respond to Expected Inflation? An Investigation of Transmission Mechanisms,
Abstract We investigate the channels through which inflation expectations affect household spending by conducting surveys featuring hypothetical scenarios involving an increase in inflation expectations. Most households did not adjust their current spending plans, often because t...