Huanggang Central Hospital

Temporal Single-Nucleus Transcriptomics Defines PPARα/CPT1A-Associated Metabolic Reprogramming During Proximal Tubular Injury and Repair

Background: Metabolic reprogramming and mitochondrial dysfunction are central features of acute kidney injury (AKI), yet their temporal relationship with proximal tubular cell-state remodeling remains incompletely understood. This study aimed to characterize early metabolic alter...

Regulation of G Protein Signaling 14 protects against cerebral ischemic reperfusion injury by inhibiting the TAK1-JNK/p38 signaling pathway.

BACKGROUND: Stroke is a crucial cause of morbidity and mortality worldwide. The regulator of G protein signaling 14 (RGS14) plays important roles in mediating multiple signaling pathways and various pathophysiological processes. However, the function of RGS14 in cerebral ischemic...

Chromosome-level genome assembly of landrace ‘Huangzhou’ provides insights into high cellulose accumulation in radish

<title>Abstract</title> Radish ( <italic>Raphanus sativus</italic> L.) is an important root vegetable crop with extensive morphological and nutritional diversity. The landrace radish, ‘Huangzhou’ (HZ) radish, origins in Huangzhou area, Hubei province of China, and characterized b...

Network analysis of frailty, sleep quality, and life satisfaction in older patients: a cross-sectional study stratified by chronic disease burden

Abstract Background Multimorbidity and chronic disease burden are common among older patients and are closely associated with frailty, poor sleep, and reduced subjective well-being. However, total-score-based analyses may obscure item-level interactions across health domains. Thi...