Huaihua University

IoT-enabled environmental monitoring and adaptive governance for ecotourism areas

Abstract Ecotourism areas require timely and adaptive environmental governance to balance ecological conservation with increasing tourism activities. However, existing studies primarily emphasize environmental sensing and data acquisition, while insufficient attention has been de...

METTL3-mediated m6A modification of RBM39 promotes cancer stemness and tumor progression in head and neck squamous cell carcinoma

Abstract Background RBM39 plays an important regulatory role in multiple cancers. However, its systematic function across pan-cancer and its specific mechanism in head and neck squamous cell carcinoma (HNSC) remain unclear. Materials and methods In this study, we performed pan-ca...

Beyond a one-size-fits-all prescription: shared and differential anti-inflammatory responses to exercise modalities in polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is a multisystem disorder in which chronic low-grade inflammation intersects with metabolic, reproductive, and psychological dysfunction, yet exercise guidance remains largely generic. This narrative review examines whether different exercise stim...

The therapeutic effect of genistein on microfracture based on network pharmacology, immune cell abundance analysis and experimental verification

Postmenopausal osteoporosis is a metabolic bone disease mainly attributed to estrogen deficiency. Genistein, a major phytoestrogen, has been reported to exert a direct suppressive effect on osteoclasts. The aim of this study was to explore the possible impact of genistein on oste...

Genetics-Informed Mapping Identifies a CRIM1-Associated Endocardial Inflammatory Remodeling State in Acute Myocardial Infarction

Background:Acute myocardial infarction (AMI) reflects inherited susceptibility and inflammatory remodeling, but the cellular contexts linking genetic risk to disease remain unclear. Material/Methods:We integrated a meta-transcriptome-wide association study (TWAS) with a human car...

Impact of Early Surgical Debridement on Outcomes in ICU Patients With Sepsis-Associated Intra-Abdominal Infection: A Retrospective Analysis

AIM: To investigate the impact of early surgical debridement, defined as a diagnosis-to-knife time (D-to-K time) ≤12 hours, on intensive care unit (ICU) outcomes in patients with sepsis-associated intra-abdominal infection.METHODS: This single-center retrospective cohort study co...