Institution
Huadong Hospital
Recent research
- Health & MedicineOpen access
Abstract Background Gastric cancer (GC) remains a major global health burden, and early detection is essential for improving patient outcomes. Although GC screening has been widely implemented in East Asian countries with a high disease burden, the optimal screening strategy for...
- Health & Medicine
Abstract Preeclampsia (PE) is a major cause of maternal and perinatal morbidity and is increasingly recognized as a disorder involving immune dysregulation. However, reliable candidate biomarkers and key molecular alterations associated with PE remain unclear. We integrated multi...
- Health & MedicineOpen access
Although immunotherapy has revolutionized cancer treatment, only a minority of head and neck squamous cell carcinoma (HNSCC) patients derive clinical benefit, underscoring the urgent need to uncover novel immune evasion mechanisms. CD24 serves as a pivotal innate immune checkpoin...
- Health & MedicineOpen access
The progression from mild cognitive impairment (MCI) to dementia represents a critical intervention window. The systemic immune-inflammation index (SII) integrates neutrophil, platelet, and lymphocyte counts and has been proposed as an accessible marker of this progression. Becau...
- Health & MedicineOpen access
Abstract Background The global burden of chronic kidney disease (CKD) is increasing significantly, with aging recognized as a major risk factor associated with accelerated biological aging and poor renal outcomes. Growing evidence links angiopoietin-like protein 4 (ANGPTL4) to bo...
- BiologyOpen access
Myf5 Progenitors Define the Lineage Identity of Somitic Vascular Smooth Muscle Cells
Vascular smooth muscle cell (VSMC) heterogeneity drives region-specific aortic pathologies, yet the roles of somite-derived lineages remain unclear. Utilizing Myf5 and MyoD lineage tracing alongside a smooth muscle-specific Myf5 conditional knockout model, we show that Myf5-deriv...
- BiologyOpen access
The Regulator of Cullins 1 (ROC1) or RING box protein-1 (RBX1) is an essential component of the largest multiunit Cullin-RING ubiquitin ligase (CRL). Previous studies demonstrated that ROC1 is frequently overexpressed in multiple malignancies, which predicts advanced cancer stage...
- Health & MedicineOpen access
To develop a non-invasive prediction model and assess its predictive power of microsatellite instability (MSI) status in gastric cancer (GC). This retrospective study included 1,012 GC patients from three hospitals during January 2019 and January 2023. Patients from hospital C we...
- Health & MedicineOpen access
Study Design Retrospective Cohort Study. Objective To propose a new technique named “lateral mass gutter” and investigate its role in augmenting spinal canal cross-sectional area (SCA) during laminoplasty. Methods This study included 105 patients who received cervical laminoplast...
- BiologyOpen access
Antibiotic heteroresistance, an unstable phenotype wherein a minority-resistant subpopulation coexists with a majority-susceptible population, can evolve to stable resistance following in vivo antibiotic exposure, thereby substantially increasing the risk of treatment failure. Ho...
- Health & MedicineOpen access
Abstract Background Digital therapeutics (DTx), a new type of intervention presented in the last few years, can be used to provide patients with access to evidence-based therapeutic interventions using high-quality software programs to achieve the purpose of treating, managing, o...
- AI & ComputingOpen access
BACKGROUND: The rapid advancement of digital pathology has opened unprecedented opportunities for intelligent diagnosis in renal cell tumor. However, there remains a significant gap in the availability of reliable deep learning models capable of comprehensive kidney cancer detect...