Houston Methodist Research Institute

Locomotor activity enhances environmental representation by boosting visuo-frontal communication

During environment exploration we rapidly acquire visual information to identify targets of interest. Here, we discovered that locomotion limits how long natural scenes are viewed dur- ing free exploration. Whether the brain has developed compensatory mechanisms to ensure that se...

Microfluidic Brillouin platform for frequency-resolved mechanics of complex fluids

We introduce an integrated microfluidic platform that combines pressure-flow rheology with depth-resolved Brillouin microspectroscopy to investigate complex fluids in extensive frequency ranges. Apparent viscosity is measured via calibrated pressure-flow in a rectangular polydime...

Functional export of NDM-7 to outer membrane vesicles in Klebsiella pneumoniae compromises imipenem and cefiderocol activity

ABSTRACT The carbapenemases KPC and NDM are the most widespread determinants of carbapenem resistance in Klebsiella pneumoniae . Whereas KPC is a soluble periplasmic serine-β-lactamase, NDM is a membrane-anchored metallo-β-lactamase (MBL), a feature that promotes its incorporatio...

Large-scale head-to-head comparison of on- and off-target profiles of [18F]Tauvid and [18F]MK6240 tau-PET in aging and Alzheimer’s disease

Abstract Background Tau-PET imaging enables in vivo quantification of neurofibrillary tangles, but tracers such as [ 18 F]Tauvid and [ 18 F]MK6240 present distinct affinities and off-target binding properties. Using the multicenter HEAD research cohort, a large-scale study design...

A stem-like CD8+ T cell reservoir resists exhaustion and sustains alloimmunity a decade after transplantation

Abstract Chronic antigen exposure is commonly thought to drive CD8 + T cells toward exhaustion. However, in transplantation, we show that sustained immunity is maintained by a persistent stem-like reservoir that iteratively replenishes short-lived cytotoxic effectors rather than...