Hotchkiss Brain Institute

IBAS: Interaction-bridged association studies discovering novel genes underlying complex traits

Genetic contributions to complex traits are often mediated through coordinated gene–gene interaction networks, yet most existing association frameworks focus on marginal single-gene effects and overlook higher-order dependency structures. Direct modeling of interactions remains c...

Exploring educators' awareness of and preparedness to respond to image-based sexual abuse and exploitation of children: A qualitative study

Background Educators and school administrators can play an important role in intervening in cases of image-based sexual abuse and exploitation of children (IBSAEC). However, these groups report they lack the knowledge and confidence to respond to suspected cases. Objective The ob...

Recent lifestyle change impacts sleep and circadian rhythms among the Indigenous peoples of Peninsular Malaysia

ABSTRACT Sleep disorders are rising globally, but their lifestyle causes remain unclear. We recorded sleep-wake patterns via actigraphy from 1036 Orang Asli adults across 12 communities in Peninsular Malaysia undergoing market integration, marked by changes in permanent infrastru...

Transcranial ultrasound stimulation of the subthalamic nucleus modulates cognitive function in humans

Transcranial ultrasound stimulation (TUS) is an emerging neuromodulation technique that can target subcortical structures with high precision. Previous research has reported basic behavioural changes with TUS; however, the capacity of TUS to modulate higher-order cognitive functi...