Hospital Universitario Virgen de las Nieves

Feasibility of a school-based cardiopulmonary resuscitation educational programme incorporating microlearning and gamification in primary school children: a prospective observational study

Abstract Cardiorespiratory arrest (CRA) is a priority public health problem whose survival depends largely on the early action of the community as the first link in the life-saving systems (chain of survival). In this context, international organisations such as the European Resu...

Neuromyelitis optica spectrum disorder associated with Kabuki syndrome: First reported case and immunopathogenic considerations

Kabuki syndrome, caused by KMT2D or KDM6A mutations, is a multisystem disorder with immune dysregulation. Its association with aquaporin-4 (AQP4) antibody–positive neuromyelitis optica spectrum disorder has not been reported. A 17-year-old male with autoimmune hypothyroidism pres...

Geographic Variation and Core Signatures of the Root Canal Microbiome: A Cross‐Country Comparative Study

AIM: Root canal infections harbour complex microbial communities that may vary across geographic populations. This study aimed to compare the root canal microbiome across Spain, Sweden, and the USA, identifying key microbial taxa, compositional and functional differences, and coh...

Impact of Chronic Spontaneous Urticaria on Major Life-Changing Decisions: An Exploratory Cross-Sectional Study

Background: Chronic Spontaneous Urticaria (CSU) profoundly impairs health-related quality of life due to intense pruritus and unpredictable flares. However, its specific influence on patients’ major life-changing decisions (MLCD)—such as career choices, family planning, and perso...

Nasoalveolar Molding and Feeding in Infants with Cleft Lip and Palate: An Exploratory Study of Parents’ and Caregivers’ Perceived Experiences

Background/Objectives: Patients with cleft lip and palate (CLP) typically experience feeding difficulties due to an abnormal communication between the oral and nasal cavities, and novel therapies such as palate tissue engineering and nasoalveolar molding (NAM) are in need to impr...

VerifyNow in acute coronary syndrome: design of the EPIC17-VERONICA trial to optimize platelet inhibition.

Introduction and objectives: De-escalation from prasugrel and ticagrelor to clopidogrel in patients undergoing percutaneous coronary intervention after acute coronary syndrome (ACS) is a strategy aimed at reducing bleeding. This study evaluates whether VerifyNow (Werfen, Spain)-g...

Disease progression in hidradenitis suppurativa: A multidimensional framework

Abstract Hidradenitis suppurativa (HS) is increasingly recognized as a progressive inflammatory disease in which recurrent follicular inflammation, tunnel formation and systemic inflammation drive cumulative, largely irreversible tissue damage, quality‐of‐life impairment and card...

Cargo-specific platelet reprogramming and education mediated by pancreatic cancer-derived extracellular vesicles

The systemic progression of pancreatic ductal adenocarcinoma (PDAC) is tied to a hypercoagulable state, yet early tumor secretome–platelet interactions remain poorly defined. Prevailing models regard platelet education by tumor-derived extracellular vesicles (EVs) as a passive, d...

Update on Perioperative Prevention of Cardiac Surgery-Associated Acute Kidney Injury

Cardiac surgery-associated acute kidney injury (CS-AKI) increases short- and long-term mortality, progression to chronic kidney disease (CKD), and healthcare costs. Its pathogenesis is multifactorial—combining renal hypoperfusion, impaired oxygen delivery, hemodilution, inflammat...

Incidence, Causes, and Outcomes of Conversion to Open Surgery During Minimally Invasive Left Pancreatectomy: A Prospective Multicenter Study

ABSTRACT Background Minimally invasive left pancreatectomy (MILP) has become the preferred approach to treat lesions of the pancreatic body and tail. However, the procedure may require conversion to open surgery, with reported conversion rates varying widely in the literature. Th...

European S2k guidelines for hidradenitis suppurativa/acne inversa Part 1. Epidemiology, diagnosis and clinical assessment

BACKGROUND: This first part of the S2k guidelines is an update of the 2015 S1 European guidelines based on the structured assessment of clinically relevant topics by the panel of experts. It is complemented by Part 2, which deals with treatments. OBJECTIVES: These guidelines aim...

Regression of Left Ventricular Hypertrophy in Primary Aldosteronism

BACKGROUND: Left ventricular hypertrophy (LVH) is frequently identified in patients with primary aldosteronism; determinants of LVH regression after targeted treatment are debated. We assessed LVH prevalence before and after adrenalectomy or mineralocorticoid receptor antagonist...

Malnutrition Severity, Morphofunctional Assessment, and Survival in Patients with Lung Cancer: A Multicentre Prospective Cohort Study

PURPOSE: Malnutrition is common in lung cancer and may contribute to impaired functional status and poor survival. This study evaluated the association between GLIM-defined malnutrition, morphofunctional nutritional parameters, and one-year mortality in patients with lung cancer....

Sex differences in epidemiology and clinical presentation of glomerular diseases in a nationwide Spanish biopsy registry

Sex differences influence the epidemiology and clinical expression of kidney diseases. Most primary glomerulonephritis shows male predominance, whereas lupus nephritis remains strongly female-biased. Large national cohorts with sex-stratified analyses are limited. We analysed all...

Prospective analysis of pre-diagnostic untargeted plasma metabolomics and risk of triple-negative breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Triple-negative breast cancer (TNBC) accounts for 10–15% of newly diagnosed breast cancer, and its aetiology is poorly understood compared to other breast cancer subtypes. We applied untargeted metabolomics to identify novel biological pathways associated with TNBC risk and poten...