Hospital Universitario Severo Ochoa

Institutionalized-Care Recommendations for Older Patients with Heart Failure

Background: Heart failure (HF) is a leading cause of hospitalization in older adults, and patients discharged to nursing homes and sociosanitary centers represent a growing and often overlooked population. The self-care recommendations of the European guidelines on HF were design...

Predicting SILENT after lithium poisoning: a multicenter cohort study and pragmatic risk stratification model

INTRODUCTION: The Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT) is a rare but potentially devastating complication of lithium poisoning. Current evidence rests on case reports and small series, leaving its true incidence, risk factors, and follow-up tools po...

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activatio...

Tumor-infiltrating lymphocytes differ across MammaPrint® classifications in breast cancer

Abstract MammaPrint® refines risk stratification in early oestrogen receptor-positive, HER2-negative breast cancer, evolving from a binary to a four-tier classification (UltraLow, Low, High-Risk1, High-Risk2). The relationship between routine histopathological features, immune in...

The narrowing sex gap in lip and oral cavity cancer incidence in Spain: Thirty years of divergent age-period-cohort trends

Background Lip and oral cavity cancer (LOCC) accounts for a significant proportion of the overall burden of head and neck cancers, yet long-term sex-specific trends remain unclear. This study aimed to analyse sex-specific LOCC incidence trends in Spain from 1994 to 2023. Methods...

Spironolactone versus Bicalutamide for Female Pattern Hair Loss: A 24-Month Unicenter Retrospective Comparative Study of Effectiveness and Safety

INTRODUCTION: Female pattern hair loss (FPHL) is a chronic, progressive condition that affects quality of life. Off-label systemic antiandrogens are increasingly used, but comparative data remain limited. METHODS: To compare the effectiveness, safety, and healthcare resource util...