Hospital Universitario Santa Cristina

MCC950-Derived NLRP3 Inflammasome Inhibitor Modulates Glial Inflammatory Signatures and Neuroinflammation after Traumatic Brain Injury

Abstract The NLRP3 inflammasome is a central mediator of sterile inflammation and a key therapeutic target to modulate secondary neuroinflammation following traumatic brain injury (TBI). Although the widely used NLRP3 inhibitor MCC950 effectively suppresses inflammasome activatio...